Navegando por Palavras-chave "polymorphism single nucleotide"

Agora exibindo 1 - 1 de 1
  • Nenhuma Miniatura disponível
    Item
    Somente Metadadados
    Polimorfismos dos genes nr3c1, chrm2, tph1 e mc1r e sua correlação com marcadores de ancestralidade e fatores biopsicossociais em indivíduos com disfunção temporomandibular
    (Universidade Federal de São Paulo (UNIFESP), 2015-05-28) Ferreira, Mariana Brandao [UNIFESP]; Alonso, Luis Garcia Alonso [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Objectives: To assess a sample of 105 patients with temporomandibular joint dysfunction (TMD) and 210 controls (control group) for the following Research Diagnostic Criteria (RDC) Axis II biopsychosocial factors: depression, pain grades, and unspecific physical symptoms with and without pain, and to determine whether certain genetic polymorphisms increase susceptibility to these factors. Methods: RDC Axis I was used for diagnosing myofascial pain in the cases. Cases and controls answered the RDC Axis II questionnaire. The DNA of cases and controls was collected and quantified. Ancestry-informative markers were identified followed by polymorphism analysis of the genes NR3C1, CHRM2, TPH1, and MC1R using TaqMan Low Density Array (TLDA) personalized cards. Results: Polymorphisms of the genes NR3C1, CHRM2, TPH1, and MC1R were not associated with depression, pain, unspecific physical symptoms with and without pain, ancestry-informative markers, or TMD. Conclusions: The multifactorial polygenic mechanism of susceptibility is based on the idea that each gene contributes with small, additive, and relatively equal effects. Hence, it is possible that the study genes have more effective interrelations with other predisposing and regulatory genes, but in isolation they do not have enough biological and statistical consistency to explain TMD. By extension, the small number of Blacks, Natives, and Asians in this sample also corroborate to the weak association between these ethnicities factors and genetic polymorphisms. Larger studies, such as the ones currently being conducted by our group, can elucidate the associations postulated above more clearly.