Navegando por Palavras-chave "papillomavirus infections"
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- ItemSomente MetadadadosCaptura híbrida para detecção do papilomavírus humano em atipias de significado indeterminado(Universidade Federal de São Paulo (UNIFESP), 2015-06-24) Ducatti, Carla [UNIFESP]; Alonso, Luis Garcia Alonso [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)Objectives: Correlate the detection of human Papillomavirus, by the method of Hybrid Capture, with the Atypia of Undetermined Significance. Among those with positive result for human Papillomavirus, define the groups found (Papillomavirus types of low and high risk) and their viral loads. Methods: This is an observational, cross-sectional and analytical study, which were entered into a database the results of cytology exams and Hybrid Capture of 474 patients from routine of cytology laboratory and Hybrid Capture of Associação Fundo Incentivo a Pesquisa (AFIP), from January 2012 to December 2013. These tests have been conducted and issued their reports. The age of patients ranged from 15 to 75 years, with an average of 33 years and 8 months. Were included diagnoses of patients who had cytological and molecular tests (CH II) in addition, positive cervical smears for Atypia of undetermined significance - ASC-US and ASC-H. Results: This study showed that 60.8% of ASC were positive in Hybrid Capture, being 58.6% for ASC-US and 83.3% for ASC-H. Regardless of the ASC subgroup, the high-risk virus was most commonly found (87.8%), either alone or associated with low-risk HPV (54.8% and 33% respectively). ASC-US demonstrated a tendency to lower viral loads, whereas ASC-H at higher viral loads. Conclusion: The method of Hybrid Capture II applied to Atypia of Undetermined Significance resulted in a positivity rate of 58.6% for ASC-US, and 83.3% for ASC-H. Regarding ASC-US, there were types "high" and "low and high risk" (53.4% and 33.2%, respectively) with low viral loads and intermediate. As the ASC-H, there were types "high" and "low and high risk" (65.8% and 31.4%, respectively) with high viral loads. Thus, in Atypia of Undetermined Significance, regardless of the subgroup, the high-risk virus was the most commonly found type, either alone or associated with low-risk HPV, and viral loads tended to rise according the severity of the atypia found in cytology.
- ItemAcesso aberto (Open Access)Laryngeal sequelae of recurrent respiratory papillomatosis surgery in children(Associação Médica Brasileira, 2012-04-01) Hermann, Juliana Sato [UNIFESP]; Pontes, Paulo [UNIFESP]; Weckx, Luc Louis Maurice [UNIFESP]; Fujita, Reginaldo Raimundo [UNIFESP]; Avelino, Melissa Ameloti Gomes [UNIFESP]; Pignatari, Shirley Shizue Nagata [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)OBJECTIVE: To evaluate laryngeal sequelae from surgical treatment of recurrent respiratory papillomatosis in children, as well as associated risk factors. METHODS: Case-control study. Medical record data analysis of 50 children with recurrent respiratory papillomatosis, divided into two groups: with and without laryngeal sequelae. The group of patients with laryngeal sequelae was compared to those without sequelae in regard to the onset of disease, age at first surgery, number and frequency of surgeries, disease stage, and type of surgery (CO2 laser, cold forceps). RESULTS: 23 patients (46%) sustained laryngeal sequelae. The most frequent sequela was anterior commissure synechia (17 patients [34%]), followed by glottic stenosis (six patients [12%]). There was no statistically significant difference between groups with and without laryngeal sequelae regarding the disease onset (p = 0.93), age at first surgery (p = 0.68), number of surgeries (p = 0.22), annual frequency of surgery (p = 0.93), presence of papilloma in anterior (p = 0.430) or posterior commissure (p = 0.39), and type of surgery (p = 0.27). The Derkay anatomical score (a staging system that assesses the extent of the disease in the aerodigestive tract) was significantly higher in the laryngeal sequelae group (p = 0.04). CONCLUSION: Laryngeal sequelae are a frequent complication of recurrent respiratory papillomatosis surgical treatment in children, particularly anterior commissure synechiae and glottic stenosis. Advanced stages are associated with increased risk of laryngeal sequelae after surgery.
- ItemAcesso aberto (Open Access)Tratamento cirurgico e terapias adjuvantes na papilomatose respiratoria(Associação Brasileira de Otorrinolaringologia e Cirurgia Cervicofacial, 2013-09-01) Avelino, Melissa Ameloti Gomes [UNIFESP]; Zaiden, Tallyta Campos Domingues Teixeira; Gomes, Raquel Oliveira; Universidade Federal de São Paulo (UNIFESP); Universidade Federal de Goias; PUC - GO; Pontificia Universidade Catolica de Goias curso de MedicinaRecurrent respiratory papillomatosis or recurrent laryngeal papillomatosis is a disease of the larynx caused by human papilloma virus, characterized by verrucous epithelial lesions and usually recurring. In the literature there are several types of treatment, such as surgery to cold, laser and/or use of microdebrider, as of adjuvant therapies; all possible to decrease the permanent sequelae of the disease.OBJECTIVE:To review the literature regarding this disease with emphasis on surgical techniques and adjuvant therapies used today.METHOD:We used the literature review, through surveys based electronic data in the public domain, to search for articles between 1992-2012, using keywords: papilloma, human pappiloma virus infection, larynx, therapeutic, papilloma virus vaccine.RESULTS:We surveyed 357 articles, of which 49 were used as the basis for this review. Scientific studies indicate a reduction of relapse in most adjuvant therapeutic presented. However, the survey showed different methodologies and samples, which did not allow to compare the types of treatment and adjuvant therapies.CONCLUSION:The choice of surgical technique varies among studies, but there is a trend to use the microdebrider. The newer adjuvant therapies, such as cidofovir, quadrivalent vaccine against human papilloma virus and bevacizumab, require further studies.
- ItemAcesso aberto (Open Access)Uso de imunomodulador tópico e papel do polimorfismo de defensinas DEFA1 e DEFB1 no tratamento de lesões intraepiteliais de vulva(Universidade Federal de São Paulo (UNIFESP), 2013-09-25) Rama, Ana Luisa de Figueiredo e Silva [UNIFESP]; Ribalta, Julisa Chamorro Lascasas [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)Purposes: Evaluate the efficacy of topical use of imiquimod 5% in the treatment of vulvar lesions type condyloma acuminated and VIN I, in comparison to expectant management. Analyze the levels of residual or recurrent lesions after the treatments mentioned above. Evaluate the efficacy of topical use of imiquimod 5% in the treatment of vulvar lesions type VIN II and VIN III, compared to the CO2 laser vaporization. Similarly, to analyze the levels of residual or recurrent lesions after treatments with topical imiquimod 5% CO2 laser vaporization. Relate the participation of polymorphisms of defensins HD1 and hBD-1 with the severity of vulvar lesions HPV-induced and the treatment responses of these lesions. Methods: Were selected 80 women with vulvar HPV-induced lesions, subdivided as histologic grade, and 51 with vulvar lesions type condyloma acuminata and VIN I in Group 1 and 29 patients with vulvar lesions type VIN II and VIN III in Group 2. In the first group the patients were subjected to a treatment with topical imiquimod 5% or expectant management, and the second group undergoing to a treatment with topical imiquimod 5% or CO2 laser vaporization. All patients answered a anamnestic questionnaire and underwent collection vulvar smears, colposcopy of the vulva and biopsy of the lesions found. The vulvar smears were submitted to the detection tests and genotyping of HPV and evaluation of polymorphisms of defensins HD1 and hBD-1. Patients were followed during treatment and after its completion followed for evaluation of residual and recurrent lesions. Results: There were statistically significant difference between the clinical response of patients in group 1 subjected to the use of topical imiquimod 5% when compared to expectant management. Residual or recurrent lesions in Group 1 were more frequent in patients who underwent to expectant management (p=0,01). In Group 2, our findings were similar in patients undergoing to a treatment with topical 5% imiquimod or CO2 laser vaporization. Our results for the presence of residual or recurrent lesions in Group 2 were similar among treatments performed, but the patients treated with topical imiquimod 5% showed recurrent lesions less severe when compared to patients who underwent to laser vaporization of CO2.There was no involvement of polymorphism of defensins HD1 and hBD-1 in severity of vulvar HPV-induced lesions. Likewise, there was no participation of polymorphism HD1 and hBD-1 in the best clinical responses. Conclusions: From these results we concluded that topical imiquimod 5% showed good results in the treatment of vulvar HPV-induced lesions, however in the vulvar lesions type VIN II / III its efficacy was similar to the CO2 laser vaporization. In Group 1, the cases referred to the use of topical imiquimod 5% had less residual or recurrent lesions, now in Group 2 it was not checked. The polymorphism of defensins HD1 and hBD-1 was not related to the severity of vulvar HPV-induced lesions, was also not associated with better clinical responses.
- ItemAcesso aberto (Open Access)Vulnerabilidade ao papiloma vírus humano em universitários de Bogotá / Colômbia(Universidade Federal de São Paulo (UNIFESP), 2014-08-08) Sepúlveda-Carrillo, Gloria Judith [UNIFESP]; Goldenberg, Paulete [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)Introduction: The Human Papilloma Virus (VPH), whether by the magnitude of its length, whether the implications in triggering of several forms of cancer, among them the cancer of the cervix, is a serious public health problem. Objective: To identify knowledge and preventive practices related to VPH infection, in view of vulnerability among the university students of Bogotá-Colombia. Method: The work consisted of three linked movements. In the first one, a systematic literature review regarding the subject of research was conducted, in order to subsidize the preparation of a questionnaire to be applied to a sample of university students. In the second movement proceeded to the construction and validation of the questionnaire. Finally, the third movement involved the application of the questionnaire among the university students of Bogota ? Colombia in 2012. Results: The literature review highlighted the limitations of knowledge by the young adult population and the urgency of conducting diagnostics able to subsidize the adoption of specific measures to deal with HPV. In the second stage, was performed content validity of questionnaire of vulnerability to HPV; showed that the questionnaire had adequate validity indicators content being approved to use. In the third step was realized a diagnosis with college students to determine knowledge and preventive practices about HPV. The study indicated that is limited, the level of student knowledge about the transmission, development and severity of HPV infection. Conclusion: In consonance with the concept of vulnerability ? the need to propose interventions in the context of public health is clearly notorious, directed towards improving knowledge about VPH, with the raising of awareness to the adoption of consistent behaviors.