Navegando por Palavras-chave "ovarian cancer"
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- ItemSomente MetadadadosAssociation of angiotensin-converting enzyme I gene I/D polymorphism with endometrial but not with ovarian cancer(Informa Healthcare, 2012-11-01) Corrêa, Silvana Aparecida Alves [UNIFESP]; Ribeiro de Noronha, Samuel Marcos [UNIFESP]; Alecrim, Cheryl [UNIFESP]; Mesquita, Adriana de Carvalho [UNIFESP]; Silva Brito, Gabriela Soares da [UNIFESP]; Junqueira, Michele Gilvana [UNIFESP]; Leite, Daniela Batista [UNIFESP]; Carvalho, Cristina Valletta de [UNIFESP]; Cotrim Guerreiro da Silva, Ismael Dale [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)Associations have been found between the angiotensin-converting enzyme insertion deletion (I/D) polymorphism (ACE I/D) and endometrial and epithelial ovarian cancer (EC and EOC, respectively). in this study, the following frequencies for each of three ACE polymorphisms, DD, ID, and II, respectively, were observed: in the EC group, 55, 24, and 21% versus the control group 39, 40, and 21% (p = 0.033*); in the EOC group 49, 36, and 15% versus the control group 49, 33, and 18% (p = 0.82). According to these allelic distributions, DD carriers are 2.0 times more likely than individuals carrying the ID or II genotypes to develop EC; therefore, the DD genotype seems to be protective against EC. in contrast, no association was observed between ACE (I/D) polymorphism with EOC. the ACE (I/D) polymorphism might play a role in the pathogenesis of EC and it should be considered when identifying genetic markers for EC.
- ItemSomente MetadadadosCanonical and noncanonical Wnt pathway: A comparison among normal ovary, benign ovarian tumor and ovarian cancer(Spandidos Publ Ltd, 2009-02-01) Badiglian Filho, Levon [UNIFESP]; Oshima, Celina Tizuko Fujiyama [UNIFESP]; Lima, Flavio de Oliveira [UNIFESP]; Costa, Henrique de Oliveira [UNIFESP]; Damiao, Roberio de Sousa [UNIFESP]; Gomes, Thiago Simao [UNIFESP]; Goncalves, Wagner Jose [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)The Wnt family is involved in tumorigenesis of several tissues. in ovarian cancer, the role played by Writs and its pathways is not clearly defined. in order to analyze the canonical and noncanonical Writ pathway in normal ovary, benign ovarian tumor and ovarian cancer, we evaluated the immunohistochemical expression of Wnt1, Frizzled-1 (FZD1), Wnt5a, Frizzled-5 (FZD5) and B-catenin. Ovarian specimens were obtained from surgeries performed between 1993 and 2004. the patients were divided in three groups: group A, epithelial ovarian cancer (n=38); group B, benign epithelial neoplasia (n=28); and group C, normal ovaries (n=26). Immunoreactivity for Wnt1, FZD1, Wnt5a, FZD5 and B-catenin was scored for each group. the proportion of Wnt1 positive women in group A (29.4%) was significantly higher than in group B (4.3%) and C (9.1%) (p=0.020). the proportion of FZD1 positive patients in group C (54.5%) was significantly lower than in group A (97.1%) and B (90.0%) (p<0.001). the proportion of Wnt5a positive women was significantly higher for group A (80.0%) compared to group B (25.0%) and C (27.3%) (p<0.001). the proportion of beta-catenin positive patients in group C (95.8%) was significantly higher than group B (52.4%) (p=0.004). Comparison of the survival curves in group A according to Wnt5a expression showed a significant difference between positive and negative patients, whereas the Wnt5a positive women showed worse results (p=0.050). Our findings suggest that the pathways related to Wnt5a have an important role in ovarian malignant neoplasia. Furthermore, Wnt5a was found to be a predictor of poor prognosis for ovarian cancer.
- ItemSomente MetadadadosP27 expression in epithelial ovarian tumors(Elsevier B.V., 2004-05-01) Patah, LEM; Camarotto, K. C.; Goncalves, Wagner Jose [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Womens Hlth Reference Ctr