Navegando por Palavras-chave "longevity"
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- ItemSomente Metadadados25(oh)vitamina d como preditor de desfechos e óbito em idosos longevos(Universidade Federal de São Paulo (UNIFESP), 2016-10-26) Pontes, Tatiana Elias de [UNIFESP]; Cendoroglo, Maysa Seabra Cendoroglo [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)25(OH) Vitamin D as Predictor of Outcomes and Death in Oldest Old One of the greatest cultural achievements of a people in their humanization process is the aging of its population, reflecting the improvement of living conditions. Some factors that contribute to active aging can benefit the raising number of oldest old people. Vitamin D and life style have shown impact on functionality and mortality. That context, this study has aimed to evaluate the relationship between serum levels of 25(OH) Vit D, outdoor activity, poor outcomes and death in independent oldest old. We selected 258 community-dwelling and independent elderly people with 80 years old or more, accompanied the Geriatrics and Gerontology Division, Federal University of São Paulo. We dose serum levels of 25(OH)D and apply a questionnaire on skin type, sun exposure and falls. We evaluated the mortality through the death certificate or register in medical records from April 2010 to March 2016. During the survival analysis, we have used the models of Kaplan-Meier and Cox. Around 70.5% were women between 80 to 89 years old (80.2%), 38.8% had daily sunlight exposure > 15 minutes and 20.1% were chronic fallers. Regarding 25(OH)D, 9.3% had serum levels < 10 ng/mL, while 76.4% between 10-30 ng/mL and 14.3% showed values > 30 ng/mL. During the observational period, 65.9% of the old oldest have stayed independent, and 17.1% have deceased. The analysis of survival time have shown that men (HR=2.7, p=0.003), over 90 years old (HR= 4.12, p < 0.001), with levels of 25(OH)VitD < 10 ng/mL (HR=3.2, p=0.004) and chronic fallers (HR=1.97, p=0.042) have shown a lower survival in comparison to the other oldest old; while women, aged 80-89 years, with a level of 25(OH) VitD > 10ng/mL and not chronic fallers, have characterized the lower risk group. Thus, we have identified that insufficient levels of 25(OH) VitD contribute to increased risk of death in the oldest old.
- ItemSomente MetadadadosThe DrugAge database of aging-related drugs(Wiley, 2017) Barardo, Diogo; Thornton, Daniel; Thoppil, Harikrishnan; Walsh, Michael; Sharifi, Samim; Ferreira, Susana; Anzic, Andreja; Fernandes, Maria; Monteiro, Patrick; Grum, Tjasa; Cordeiro, Rui; De-Souza, Evandro Araujo [UNIFESP]; Budovsky, Arie; Araujo, Natali; Gruber, Jan; Petrascheck, Michael; Fraifeld, Vadim E.; Zhavoronkov, Alexander; Moskalev, Alexey; de Magalhaes, Joao PedroAging is a major worldwide medical challenge. Not surprisingly, identifying drugs and compounds that extend lifespan in model organisms is a growing research area. Here, we present DrugAge (http://genomics. senescence. info/drugs/), a curated database of lifespan-extending drugs and compounds. At the time of writing, DrugAge contains 1316 entries featuring 418 different compounds from studies across 27 model organisms, including worms, flies, yeast and mice. Data were manually curated from 324 publications. Using drug-gene interaction data, we also performed a functional enrichment analysis of targets of lifespan-extending drugs. Enriched terms include various functional categories related to glutathione and antioxidant activity, ion transport and metabolic processes. In addition, we found a modest but significant overlap between targets of lifespan-extending drugs and known aging-related genes, suggesting that some but not most aging-related pathways have been targeted pharmacologically in longevity studies. DrugAge is freely available online for the scientific community and will be an important resource for biogerontologists.
- ItemAcesso aberto (Open Access)Human longevity is associated with regular sleep patterns, maintenance of slow wave sleep, and favorable lipid profile(Frontiers Research Foundation, 2014-06-24) Mazzotti, Diego Robles [UNIFESP]; Guindalini, Camila [UNIFESP]; Moraes, Walter Andre dos Santos [UNIFESP]; Andersen, Monica Levy [UNIFESP]; Cendoroglo, Maysa Seabra [UNIFESP]; Ramos, Luiz Roberto [UNIFESP]; Tufik, Sergio [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)Some individuals are able to successfully reach very old ages, reflecting higher adaptation against age-associated effects. Sleep is one of the processes deeply affected by aging; however few studies evaluating sleep in long-lived individuals (aged over 85) have been reported to date. the aim of this study was to characterize the sleep patterns and biochemical profile of oldest old individuals (N = 10, age 85-105 years old) and compare them to young adults (N = 15, age 20-30 years old) and older adults (N = 13, age 60-70 years old). All subjects underwent full-night polysomnography, 1-week of actigraphic recording and peripheral blood collection. Sleep electroencephalogram spectral analysis was also performed. the oldest old individuals showed lower sleep efficiency and REM sleep when compared to the older adults, while stage N3 percentage and delta power were similar across the groups. Oldest old individuals maintained strictly regular sleep-wake schedules and also presented higher HDL-cholesterol and lower triglyceride levels than older adults. the present study revealed novel data regarding specific sleep patterns and maintenance of slow wave sleep in the oldest old group. Taken together with the favorable lipid profile, these results contribute with evidence to the importance of sleep and lipid metabolism regulation in the maintenance of longevity in humans.
- ItemAcesso aberto (Open Access)Parameters of the immune system and Vitamin D levels in Old individuals(Frontiers Media Sa, 2018) Alves, Amanda Soares [UNIFESP]; Ishimura, Mayari Eika [UNIFESP]; Duarte, Yeda Aparecida de Oliveira; Bueno, Valquíria [UNIFESP]Aim: The increased number of individuals older than 80 years, centenarians, and super centenarians is not a synonym for healthy aging, since severe infections, hospitalization, and disability are frequently observed. In this context, a possible strategy is to preserve the main characteristics/functions of the immune system with the aim to cause less damage to the organism during the aging process. Vitamin D acts on bone marrow, brain, breast, malignant cells, and immune system and has been recommended as a supplement. We aimed to evaluate whether immune parameters and vitamin D serum levels are correlated. Methods: We evaluated some features of the immune system using the peripheral blood of individuals older than 80 years (n = 12) compared to young subjects (n = 10). In addition, we correlated these findings with vitamin D serum levels. Results: Old individuals presented metabolic parameters of healthy aging and maintained preserved some features of immunity such as CD4/CD8 ratio, and low production of pro-inflammatory cytokines after stimulus. On the other hand, we observed increase in the frequency of myeloid-derived suppressor cells, reduction in circulating leukocytes, in the percentage of total CD8+, and in CD8+ Nafve T cells, in addition to increase in the percentage of CD8+ effector memory re-expressing CD45RA (EMRA) T cells. We found seropositivity for CMV in 97.7%, which was correlated with the decrease of CD8+ Naive T cells and increase in CD8+ EMRA T cells. Vitamin D levels were insufficient in 50% of old individuals and correlated positively with total CD8+ T cells and negatively with CD8+ EMRA T cells. Conclusion: In the studied population, longevity was correlated to maintenance of some immune parameters. Considering the limitations of the study as size of the sample and lack of functional assays, it was found that vitamin D in old individuals was correlated to some features of the immune system, mainly in the CD8 compartment.
- ItemSomente MetadadadosA statistical model to select densities of Apis mellifera bees in conducting laboratory experiments(Entomological Soc Southern Africa, 2013-09-01) Cirillo, Marcelo Angelo; Cespedes, Juliana Garcia [UNIFESP]; Universidade Federal de Lavras (UFLA); Universidade Federal de São Paulo (UNIFESP)The survival of Apis mellifera Linnaeus, 1758 adults under laboratory conditions is not ensured only by a well-balanced diet during the larval stage and the first days after emergence; their population density in each experimental unit also affects the longevity of these insects. In this context, where statistical techniques allow considering random effects, fixed and different, covariance structures are interesting to build models that add information to bees confined to the laboratory. The goal of this paper was to study bee mortality in an experiment with different densities in each experimental unit observed over time. The statistical analyses used a mixed model with a covariance structure AR(1) and concluded that the average mortality rate for the bees is less progressive when considering densities with 50 individuals in each experimental unit.