Navegando por Palavras-chave "latent tuberculosis infection"

Agora exibindo 1 - 2 de 2
  • Nenhuma Miniatura disponível
    Item
    Somente Metadadados
    Rate of tuberculosis infection in children and adolescents with household contact with adults with active pulmonary tuberculosis as assessed by tuberculin skin test and interferon-gamma release assays
    (Cambridge Univ Press, 2016) Ferrarini, M. A. G. [UNIFESP]; Spina, F. G. [UNIFESP]; Weckx, L. Y. [UNIFESP]; Lederman, H. M. [UNIFESP]; De Moraes-Pinto, M. I. [UNIFESP]
    Tuberculosis (TB) infection was evaluated in Brazilian immunocompetent children and adolescents exposed and unexposed (control group) to adults with active pulmonary TB. Both groups were analysed by clinical and radiological assessment, TST, QFT-IT and T-SPOT. TB. The three tests were repeated after 8 weeks in the TB-exposed group if results were initially negative. Individuals with latent tuberculosis infection (LTBI) were treated and tests were repeated after treatment. Fifty-nine TB-exposed and 42 controls were evaluated. Rate of infection was 69.5% and 9.5% for the exposed and control groups, respectively. The exposed group infection rate was 61% assessed by TST, 57.6% by T-SPOT. TB, and 59.3%, by QFT-IT. No active TB was diagnosed. Agreement between the three tests was 83.1% and 92.8% in the exposed and control groups, respectively. In the exposed group, T-SPOT. TB added four TB diagnoses [16%, 95% confidence interval (CI) 1.6-30.4] and QFT-IT added three TB diagnoses (12%, 95% CI 0-24.7) in 25 individuals with negative tuberculin skin test (TST). Risk factors associated to TB infection were contact with an adult with active TB [0-60 days: odds ratio (OR) 6.9; >60 days: OR 27.0] and sleeping in the same room as an adult with active TB (OR 5.2). In Brazilian immunocompetent children and adolescents, TST had a similar performance to interferon-gamma release assays and detected a high rate of LTBI.
  • Nenhuma Miniatura disponível
    Item
    Somente Metadadados
    Tuberculose ativa e infecção latente por tuberculose entre portadores de hepatite c
    (Universidade Federal de São Paulo (UNIFESP), 2016-12-21) Uehara, Silvia Naomi de Oliveira [UNIFESP]; Ferraz, Maria Lucia Cardoso Gomes Ferraz [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Brazil is one of the 22 countries that concentrates 80% of global tuberculosis (Tb) cases concomitantly to a large number of hepatitis C carriers and some epidemiological risk scenarios are coincident for both diseases. We analyzed Tb cases that occurred during ?-interferon-based (?-IFN-based) therapy for hepatitis C in reference centers in Brazil between 2001 and 2012 and reviewed their medical records. Eighteen Tb cases were observed in patients submitted to hepatitis C ?-IFN-based therapy. All patients were human immunodeficiency virus-negative. Nine patients (50%) had extra-pulmonary Tb; 15 (83%) showed significant liver fibrosis. Hepatitis C treatment was discontinued in 12 patients (67%) due to Tb reactivation and six (33%) had sustained virological response (SVR). The majority of patients had a favorable outcome but one died. Considering the evidences of ?-IFN interference over the containment of M. tuberculosis, the immune impairment of cirrhotic patients, the increase of Tb case reports during hepatitis C treatment with atypical and severe presentations and the negative impact on SVR, we think these are strong arguments for latent tuberculosis infection (LTBI) screening before starting ?-IFN-based therapy for any indication and even to consider IFN-free regimens against hepatitis C when a patient tests positive for LTBI. hepatitis C; tuberculosis; alpha-interferon; latent tuberculosis infection.