Navegando por Palavras-chave "líquido cefalorraquidiano"
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- ItemAcesso aberto (Open Access)Líquido cefalorraquiano no diagnóstico de metástase cérebro-meníngea de melanoma maligno derivado de nevo melanocítico gigante congênito: relato de caso(Academia Brasileira de Neurologia - ABNEURO, 1996-09-01) Rolim, José Augusto B. [UNIFESP]; Barsottini, Orlando Graziani Povoas [UNIFESP]; Prado, Gilmar Fernandes do [UNIFESP]; Nakandakare, Fernando [UNIFESP]; Reis, Maria L. A. A. [UNIFESP]; Reis-Filho, J. B. [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)We describe the case of a 28-year-old man with a giant congenital melanocytic nevus (GCMN) with malignant transformation to melanoma and metastasis on the central nervous system (CNS). We also make a summary of the pathological features from both lesions(GCMN and melanoma), the occurrence of malignancy of GCMN, the organs more frequently involved with metastatic melanoma - with emphasis to involvement of CNS -just as the factors that cause malignant transformation of GCMN; the methods to diagnose metastases in CNS - emphasizing the importance of cerebrospinal fluid - and some therapeutical modalities for the metastatic melanoma in CNS.
- ItemAcesso aberto (Open Access)Líquido cefalorraquidiano no diagnóstico da esquistossomose raquimedular(Academia Brasileira de Neurologia - ABNEURO, 2005-09-01) Tesser, Egídio; Reis, Maria de Lourdes Amud Ali dos [UNIFESP]; Borelli, Primavera; Matas, Sandro Luiz de Andrade [UNIFESP]; Reis Filho, João Baptista dos [UNIFESP]; Universidade Estadual de Londrina Centro de Ciências da Saúde; Universidade Federal de São Paulo (UNIFESP); Universidade de São Paulo (USP)Cerebrospinal fluid (CSF) changes in spinal shistosomiasis have been described. Its characteristic features are mild to moderate pleocytosis, presence of eosinophils, slight to moderate protein increase, elevated gamma globulin concentration and a positive immune assay. Nevertheless, these abnormalities are not always present together and therefore difficulties may arise in the assessment of the diagnosis. The purpose of this paper is to evaluate the importance of each CSF alteration concerning the diagnosis in 22 cases of spinal shistosomiasis. According to the results, only 20% of the cases had all the five feature that are considered to be characteristic of spinal shistomiasis. Abnormal cell count was present in 86%, protein increase in 77.3%, immunoglobulin G increase in 60,8%, eosinophils were present in 36.8% and indirect fluorescent antibody test was positive in 68.2%. In three cases all CSF parameters studied were within the normal limits. As the most specific test among those described was the indirect fluorescent antibody test, it should be regarded for the diagnosis.
- ItemAcesso aberto (Open Access)Quantification of Fas protein in CSF of patients with neurocysticercosis(Academia Brasileira de Neurologia - ABNEURO, 2012-04-01) Camargo, José Augusto [UNIFESP]; Bertolucci, Paulo Henrique Ferreira [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)Neurocysticercosis is a parasitic disease that affects the central nervous system. The objective of this study was to investigate the correlation between neuronal death evaluated by the quantification of Fas apoptotic factor and the different evolutive forms of neurocysticercosis accompanied or not by epileptic seizures. METHODS: Cerebrospinal fluid samples from 36 patients with a diagnosis of neurocysticercosis divided into the following groups: active cystic form (n=15), 9 patients with and 6 without seizures, and calcified form (=21), 9 with and 12 without seizures. Fourteen patients comprised the control group. Fas protein concentrations were determined by ELISA. RESULTS: Only the group of patients with calcified cysts without seizures presented cerebrospinal fluid levels of Fas similar to those of the control group. Higher levels were observed for the other groups. CONCLUSIONS: The present finding suggests high cerebrospinal fluid levels of soluble Fas protein, except for patients with calcified cysts without seizures. Significant differences were observed for the group with calcified cysts and seizures, suggesting greater neuronal damage in these patients. Replacement of the term inactive cyst with reactive inactive cyst is suggested.
- ItemAcesso aberto (Open Access)Traditional biomarkers in narcolepsy: experience of a Brazilian sleep centre(Academia Brasileira de Neurologia - ABNEURO, 2010-10-01) Coelho, Fernando Morgadinho Santos [UNIFESP]; Pradella-Hallinan, Márcia Lurdes de Cássia [UNIFESP]; Pedrazzoli, Mario [UNIFESP]; Soares, Carlos Augusto Senne; Fernandes, Gustavo Bruniera Peres; Gonçalves, André Leite; Tufik, Sergio [UNIFESP]; Bittencourt, Lia Rita Azeredo [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Israelita Albert Einstein HospitalThis study was thought to characterized clinical and laboratory findings of a narcoleptic patients in an out patients unit at São Paulo, Brazil. METHOD: 28 patients underwent polysomnographic recordings (PSG) and Multiple Sleep Latency Test (MSLT) were analyzed according to standard criteria. The analysis of HLADQB1*0602 allele was performed by PCR. The Hypocretin-1 in cerebral spinal fluid (CSF) was measured using radioimmunoassay. Patients were divided in two groups according Hypocretin-1 level: Normal (N) - Hypocretin-1 higher than 110pg/ml and Lower (L) Hypocretin-1 lower than 110 pg/ml. RESULTS: Only 4 patients of the N group had cataplexy when compared with 14 members of the L group (p=0.0002). DISCUSSION: This results were comparable with other authors, confirming the utility of using specific biomarkers (HLA-DQB1*0602 allele and Hypocretin-1 CSF level) in narcolepsy with cataplexy. However, the HLADQB1*0602 allele and Hypocretin-1 level are insufficient to diagnose of narcolepsy without cataplexy.