Navegando por Palavras-chave "infecções por papillomavirus"

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    Uso de imunomodulador tópico e papel do polimorfismo de defensinas DEFA1 e DEFB1 no tratamento de lesões intraepiteliais de vulva
    (Universidade Federal de São Paulo (UNIFESP), 2013-09-25) Rama, Ana Luisa de Figueiredo e Silva [UNIFESP]; Ribalta, Julisa Chamorro Lascasas [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Purposes: Evaluate the efficacy of topical use of imiquimod 5% in the treatment of vulvar lesions type condyloma acuminated and VIN I, in comparison to expectant management. Analyze the levels of residual or recurrent lesions after the treatments mentioned above. Evaluate the efficacy of topical use of imiquimod 5% in the treatment of vulvar lesions type VIN II and VIN III, compared to the CO2 laser vaporization. Similarly, to analyze the levels of residual or recurrent lesions after treatments with topical imiquimod 5% CO2 laser vaporization. Relate the participation of polymorphisms of defensins HD1 and hBD-1 with the severity of vulvar lesions HPV-induced and the treatment responses of these lesions. Methods: Were selected 80 women with vulvar HPV-induced lesions, subdivided as histologic grade, and 51 with vulvar lesions type condyloma acuminata and VIN I in Group 1 and 29 patients with vulvar lesions type VIN II and VIN III in Group 2. In the first group the patients were subjected to a treatment with topical imiquimod 5% or expectant management, and the second group undergoing to a treatment with topical imiquimod 5% or CO2 laser vaporization. All patients answered a anamnestic questionnaire and underwent collection vulvar smears, colposcopy of the vulva and biopsy of the lesions found. The vulvar smears were submitted to the detection tests and genotyping of HPV and evaluation of polymorphisms of defensins HD1 and hBD-1. Patients were followed during treatment and after its completion followed for evaluation of residual and recurrent lesions. Results: There were statistically significant difference between the clinical response of patients in group 1 subjected to the use of topical imiquimod 5% when compared to expectant management. Residual or recurrent lesions in Group 1 were more frequent in patients who underwent to expectant management (p=0,01). In Group 2, our findings were similar in patients undergoing to a treatment with topical 5% imiquimod or CO2 laser vaporization. Our results for the presence of residual or recurrent lesions in Group 2 were similar among treatments performed, but the patients treated with topical imiquimod 5% showed recurrent lesions less severe when compared to patients who underwent to laser vaporization of CO2.There was no involvement of polymorphism of defensins HD1 and hBD-1 in severity of vulvar HPV-induced lesions. Likewise, there was no participation of polymorphism HD1 and hBD-1 in the best clinical responses. Conclusions: From these results we concluded that topical imiquimod 5% showed good results in the treatment of vulvar HPV-induced lesions, however in the vulvar lesions type VIN II / III its efficacy was similar to the CO2 laser vaporization. In Group 1, the cases referred to the use of topical imiquimod 5% had less residual or recurrent lesions, now in Group 2 it was not checked. The polymorphism of defensins HD1 and hBD-1 was not related to the severity of vulvar HPV-induced lesions, was also not associated with better clinical responses.
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    Vulnerabilidade ao papiloma vírus humano em universitários de Bogotá / Colômbia
    (Universidade Federal de São Paulo (UNIFESP), 2014-08-08) Sepúlveda-Carrillo, Gloria Judith [UNIFESP]; Goldenberg, Paulete [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Introduction: The Human Papilloma Virus (VPH), whether by the magnitude of its length, whether the implications in triggering of several forms of cancer, among them the cancer of the cervix, is a serious public health problem. Objective: To identify knowledge and preventive practices related to VPH infection, in view of vulnerability among the university students of Bogotá-Colombia. Method: The work consisted of three linked movements. In the first one, a systematic literature review regarding the subject of research was conducted, in order to subsidize the preparation of a questionnaire to be applied to a sample of university students. In the second movement proceeded to the construction and validation of the questionnaire. Finally, the third movement involved the application of the questionnaire among the university students of Bogota ? Colombia in 2012. Results: The literature review highlighted the limitations of knowledge by the young adult population and the urgency of conducting diagnostics able to subsidize the adoption of specific measures to deal with HPV. In the second stage, was performed content validity of questionnaire of vulnerability to HPV; showed that the questionnaire had adequate validity indicators content being approved to use. In the third step was realized a diagnosis with college students to determine knowledge and preventive practices about HPV. The study indicated that is limited, the level of student knowledge about the transmission, development and severity of HPV infection. Conclusion: In consonance with the concept of vulnerability ? the need to propose interventions in the context of public health is clearly notorious, directed towards improving knowledge about VPH, with the raising of awareness to the adoption of consistent behaviors.