Navegando por Palavras-chave "fígado"

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    Efeitos das experiências adversas precoces e tardias no comportamento alimentar e morfologia da glândula adrenal, fígado e baço de ratos sprague-dawley submetidos ao estresse na vida adulta
    (Universidade Federal de São Paulo (UNIFESP), 2016-11-29) Pastene, Belgica Katuscha Vasquez [UNIFESP]; Smith, Ricardo Luiz Smith [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Early interruption of maternal bonding and social isolation are variables involved in social and emotional behavior, which can cause increased anxiety, especially in stressful situations. However, there is no research to explain the phenomenon of overeating anxiety disorder associated with these factors in an animal model and their effects on the morphology of the adrenal gland (AG), liver and spleen. Henceforth, the objective of this research was to determine the effects of early and late intake behavior in adrenal gland, liver and spleen morphology of Sprague-Dawley rats subjected to chronic stress during adulthood. We used 35 newborn female rats, maintained under standardized suckling and feeding conditions. The rats were randomized into 2 control groups (C1 and C2) and 3 experimental groups exposed to an early adverse experience (E1), late (E2) and early-late (E3) subsequently subjected to chronic intermittent stress in adulthood (C2, E1, E2 and E3). Intake behavior of groups and morphological changes of the left AG, the liver and spleen were evaluated by determining morphometric and stereological parameters for each organ. The early and late adverse experiences are factors that influence coping with a stressful situation favoring increased caloric intake and palatable food choice. The morphological features of the AG, the liver and spleen of rats can be affected by exposure to chronic stress, however, when individuals have undergone previous adverse experiences, these changes are more obvious.
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    Estudo sobre a etiologia e o estado funcional de portadores de cirrose hepática atendidos em um serviço de referência em hepatologia
    (Universidade Federal de São Paulo (UNIFESP), 2015-08-20) Monteiro, Mirella Medeiros [UNIFESP]; Carvalho Filho, Roberto Jose de Carvalho Filho [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Introduction: It is estimated that approximately 1% of the world population have cirrhosis, which is the 14° cause of death worldwide. Detailed studies of the main causes of advanced liver disease in Brazil are fundamental to the development of appropriate policies of Public Health. Objective: To evaluate the etiology of liver cirrhosis and functional status of patients with cirrhosis at a specialized outpatient of tertiary / quaternary health care center. Methods: Cross-sectional study that included all patients with liver cirrhosis followed in specialized clinics between January / 2010 and June / 2015. The diagnosis of cirrhosis was based on clinical, laboratory, imaging and histological features. Demographic, biochemical, serological and histological variables were used to evaluate the cause of liver disease and characterize liver function at the start of follow-up. Results: We included 568 patients. Liver biopsy was performed in 92/568 (16%) of the sample. Alcoholic liver disease (ALD) is the most common etiology (60%). Among these, hepatic comorbidities were identified: hepatitis C in 6%; hepatitis B 1%; metabolic steatosis in schistosomiasis 2% and 2%. Hepatitis C is the second most common cause of cirrhosis 19%. Only 6% of patients were diagnosed related autoimmune diseases. The prevalence of schistosomiasis was 9% (n = 48), and in 22 cases (4% of the total), there were no other causes of liver disease. Cryptogenic cirrhosis was seen in 4% of cases. Genetic metabolic diseases and vascular liver diseases constituted minority vascular causes (1.4 and 1.6%, respectively). The prevalence of obesity (BMI ? 30) was 25%. Ascites was observed in 32% of cases and esophageal varices were found in 79% of patients (46% of medium / large gauges). As the Child-Pugh-Turcotte score (CPT), the patients were classified as early in the outpatient follow: CPT A 49%, CPT B in 40% and 11% in CPT C. Conclusions: In this study, the most common cause of cirrhosis was the ALD (60%). From a functional point of view, approximately 50% of patients were decompensated at the beginning of outpatient. Given its high prevalence and high morbidity and mortality, it is urgent to establish effective strategies for early diagnosis and treatment of alcoholism and ALD in Brazil
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    Papel da oxigenação hiperbárica na expressão gênica do estresse oxidativo e defesa antioxidante na isquemia e reperfusão hepática em camundongos
    (Universidade Federal de São Paulo (UNIFESP), 2016-12-21) Chaves, Jose Carlos [UNIFESP]; Fagundes, Djalma Jose [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Objective: to evaluate the role of hyperbaric oxygen in the gene expression related to oxidative stress and the antioxidant response on the liver of isogenic mice submitted to ischemia and reperfusion. Methods: Thirty mice (C57BL / 6) underwent anesthesia, laparotomy and at 60 minute intervals of ischemia and 60 minutes of hepatic reperfusion. Three groups were treated with hyperbaric oxygen (GHBO) during different periods: during ischemia (GHBO+I), during reperfusion (GHBO+R) and during ischemia and reperfusion (GHBO+IR). Six animals submitted to IR did not receive HBO (GIR). Six other animals were not submitted to I/R or HBO (GC). Real-time Chain Polymerase Reaction (RT-qPCR) evaluated gene expression. From the 84 analyzable genes were traced by relevance the genes encoding the SOD1 and SOD2 isoforms of the superoxide dismutase and glutathione peroxidase GPX1 and GPX4. Results: the gene expression were; SOD1 => GIR (+10.23), HBO/I (+16.63), HBO/R (+11.577,21), HBO / IR (+35.38); SOD2 => GIR (+5.39), HBO / I (+10.49), HBO / R (+4.266,98), HBO / IR (+16.85); GPX1 => GIR (+7.81), HBO / I (+10.94), HBO / R (+23,888.03), HBO / IR (+25.81); GPX4 => GIR (+4.87), HBO/I (+2.87), HBO/R (+26,782.44), HBO/IR (+9.35). Conclusions: hyperbaric oxygen promoted increased expression of the genes that encode oxidative stress and antioxidant defense, with the most favorable result when applied during ischemia and the deleterious result when applied during reperfusion.