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- ItemSomente MetadadadosAcute action of aminophylline in patients with amyotrophic lateral sclerosis(Blackwell Publishing, 2007-05-01) Berto, M. C.; Filha, S. C.; Camelier, A.; Rosa, F. W.; Oliveira, A. de Souza Bulle; Jardim, J. R.; Universidade Federal de São Paulo (UNIFESP)Objective - This study investigated whether aminophylline has an acute effect on the muscle performance of patients with amyotrophic lateral sclerosis (ALS). the study was a randomized, double-blind, crossover against placebo. Materials and methods - Twenty-five patients (48.5 +/- 14.1 years) with ALS were evaluated by means of forced vital capacity (FVC), maximal mouth inspiratory and expiratory pressures (P-Imax/P-Emax) and endurance, maximum voluntary ventilation (MVV) and handgrip strength (HS); variables were measured before and after the patients received an intravenous infusion of aminophylline or placebo. Results - MVV (P < 0.02) and HS of the right and left hands (P = 0.05) increased after aminophylline infusion. There was a positive correlation between FVC and P-Imax (r = 0.80; P < 0.05); between MVV and P-Imax post-aminophylline, respectively (r = 0.77; P < 0.05). Serum aminophylline levels ranged from 5.3 to 10.5 mu g/mL (mean 7.30). Conclusion - the acute administration of aminophylline improves the endurance of respiratory muscles and increases handgrip strength in patients with ALS.
- ItemAcesso aberto (Open Access)Da estética da existência como resistência ao intolerável: por uma ontologia do sujeito(Universidade Federal de São Paulo (UNIFESP), 2016-03-28) Brandao, Ramon Taniguchi Piretti [UNIFESP]; Teixeira, Ana Lucia de Freitas [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)The present research studies the question of ontology of the subject, which marks the thought of Michel Foucault. In this context, we investigate the ways in which the individual, since antiquity, it is recognized as a subject of its own shares. This constitution, as we shall see, takes place from a relationship, that the individual establishes himself (ethical relation) and historical events in the context of knowing the power characteristic of his time. On the other side, we will see that crystallized thought patterns always leave space for the exercise of a transgressive resistance, experience of struggle where the individual creates new possibilities of life. The author tells us that the individual?s subjective process, taking an ethical position, walks toward the aesthetics of existence, possible freedom in existence. In other words, the subject of experience is organized from a principle of transformation, a form of action which he conceives in becoming, being the node of multiple relationships and not from an identity principle, where it presupposes unit.
- ItemSomente MetadadadosRELATIONSHIP BETWEEN PERIPHERAL MUSCLE STRUCTURE and FUNCTION in PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE WITH DIFFERENT NUTRITIONAL STATUS(Lippincott Williams & Wilkins, 2011-07-01) Malaguti, Carla [UNIFESP]; Napolis, Lara M. [UNIFESP]; Villaca, Debora [UNIFESP]; Neder, Jose A. [UNIFESP]; Nery, Luiz E. [UNIFESP]; Dal Corso, Simone [UNIFESP]; Nove Julho Univ; Universidade Federal de São Paulo (UNIFESP)Malaguti, C, Napolis, LM, Villaca, D, Neder, JA, Nery, LE, and Dal Corso, S. Relationship between peripheral muscle structure and function in patients with chronic obstructive pulmonary disease with different nutritional status. J Strength Cond Res 25(7): 1795-1803, 2011-The purpose of this study was to investigate the relationships between peripheral muscle structure (mass) and function (strength, endurance, and maximal aerobic capacity) in patients with chronic obstructive pulmonary disease (COPD) with different nutritional states. Thirty-nine patients (31 male) with moderate-severe COPD (63.5 +/- 7.3 [SD] years) and 17 controls (14 male; 64.7 +/- 5.5 [SD] years) underwent isokinetic (peak torque [PT]), isometric (isometric torque [IT]), and endurance strength (total work [TW]) measurements of the knee extensor muscles and a maximal cardiopulmonary exercise test to evaluate the maximal aerobic capacity (peak oxygen uptake [<(V)over dot>O-2] peak). Muscle mass (MM) was determined using dual-energy x-ray absorptiometry. Patients with COPD presented with reduced muscle function as compared with the healthy controls: PT (105.9 +/- 33.9 vs. 134.3 +/- 30.9, N.m(-1), respectively, p < 0.05), TW (1,446.3 +/- 550.8 vs. 1,792.9 +/- 469.1 kJ, respectively, p < 0.05), and <(V)over dot>(2)peak (68.1 +/- 15.1 vs. 93.7 +/- 14.5, % pred, respectively, p, 0.05). Significant relationships were found between muscle structure and function (strength and endurance) in the patient subgroup with preserved MM and in the control group: PT.MM-1(r(2) = 0.36; p = 0.01 vs. r(2) = 0.32; p = 0.01, respectively) and TW.MM-1 (r(2) = 0.32; p = 0.01 vs. r(2) = 0.22; p = 0.05, respectively). Strength corrected for mass normalized this function in both patient subgroups, whereas endurance was normalized only in the patient subgroup without muscle depletion. Maximal aerobic capacity remained reduced, despite the correction, in both patient subgroups (depleted or nondepleted) compared with the healthy controls (<(V)over dot>(2)peak.MM-1: 9.1 +/- 3.7 vs. 21.8 +/- 4.9 vs. 28.5 +/- 4.2 ml.min.kg(-1), respectively, with p < 0.01 among groups). Muscle atrophy seems to be the main determinant of strength reduction among patients with moderate-severe COPD, whereas endurance reduction seems to be more related to imbalance between oxygen delivery and consumption than to the local muscle structure itself. Peripheral MM did not constitute a good predictor for maximal aerobic capacity in this population. the main practical application of this study is to point out a crucial role for the strategies able to ameliorate cardiorespiratory and muscular fitness in patients with COPD, even in those patients with preserved MM.