Navegando por Palavras-chave "doença celíaca"
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- ItemAcesso aberto (Open Access)Calcificação intracraniana occipital bilateral, epilepsia e doença celíaca: relato de caso(Academia Brasileira de Neurologia - ABNEURO, 2002-09-01) Santos, Carlos Henrique Souza [UNIFESP]; Almeida, Iara Leda Brandão de [UNIFESP]; Gomes, Maria Durce Costa [UNIFESP]; Serafim, Alexandre [UNIFESP]; Pereira, Mariana Machado [UNIFESP]; Muszkat, Mauro [UNIFESP]; Rizzutti, Sueli [UNIFESP]; Patricio, Francy Reis da Silva [UNIFESP]; Miranda, Mônica Carolina [UNIFESP]; Vilanova, Luiz Celso Pereira [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)We report a case of a six-year-old girl with frequent diarrhea episodes associated with ferroprive anemia from 6 months of age, normal neuromotor development and partial seizures initiated in her 3rd year which was controlled with carbamazepine. CT scan in her 5th year of age demonstrated gyral calcifications in the occipital and posterior parietal regions bilaterally. MRI has shown low signal areas in the axial T2 sequences corresponding to the gyral calcifications evident on the CT. Blood investigation for coeliac disease with antigliadin, endomysial and transglutaminase antibodies was positive and the intestinal biopsy has showed villous atrophy associated with an increased number of intraepithelial lymphocytes and hypertrophic criptae compatible with coeliac disease.
- ItemAcesso aberto (Open Access)Doença celíaca e constipação: uma manifestação clínica atípica e pouco frequente(Sociedade de Pediatria de São Paulo, 2012-06-01) Boé, Cristiane [UNIFESP]; Lozinsky, Adriana Chebar [UNIFESP]; Patricio, Francy Reis da Silva [UNIFESP]; Andrade, Jacy Alves Braga de [UNIFESP]; Fagundes-Neto, Ulysses [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)OBJECTIVE: To report two cases of patients with celiac disease (CD) whose main complaint was chronic constipation. CASE DESCRIPTION: Two girls, aged 18 and 30 months, had chronic constipation refractory to standard treatment. Both patients concomitantly evidenced low weight gain and short stature. The investigation of the digestive-absorptive function was positive for IgA antibodies against tissue transglutaminase. The diagnosis of CD was confirmed by a small bowel biopsy that showed moderate/severe villous atrophy and increased intraepithelial lymphocytic infiltration. One month after starting the dietary treatment with a gluten-free diet, both patients recovered from constipation, with the passage of soft stools daily. COMMENTS: CD may be presented in the classical, asymptomatic or atypical forms. In the latter form, isolated manifestations, surch as constipation, delay the diagnosis of the disease.
- ItemAcesso aberto (Open Access)Doença celíaca em tratamento: avaliação da densidade mineral óssea(Sociedade Brasileira de Pediatria, 2003-08-01) Carvalho, Cecília Noronha De Miranda; Sdepanian, Vera Lucia [UNIFESP]; Morais, Mauro Batista de [UNIFESP]; Fagundes Neto, Ulysses [UNIFESP]; Universidade Estadual do Rio de Janeiro; Universidade Federal de São Paulo (UNIFESP)OBJECTIVE: the present study was designed to compare the bone mineral density of children and adolescents with celiac disease to the bone mineral density of controls, and to evaluate laboratory analysis of calcium metabolism of celiac disease patients. METHODS: thirty celiac disease patients (17 children, 13 adolescents), on a gluten-free diet, and 23 healthy subjects were studied. Tests of bone mineral density of the lumbar spine (DEXA, Lunar) were performed in all patients and controls. Laboratory analysis of calcium metabolism was performed in all patients. RESULTS: mean weight and height of adolescents with celiac disease were lower than mean weight and height of controls (p<0.05). Bone mineral density in adolescents with celiac disease was significantly reduced if compared to controls (p=0.015), whereas no significant difference was found among children with celiac disease and controls. The number of adolescents who had started a gluten-free diet after the age of 2 years was higher than in children (p=0.003). Serum levels of ionized calcium, total calcium and parathormone were normal. CONCLUSIONS: the one mineral density of adolescents with celiac disease was lower than controls; whereas, no difference was found between the bone mineral density of children with celiac disease and controls.
- ItemAcesso aberto (Open Access)Effect of incorporation of amaranth on the physical properties and nutritional value of cheese bread(Sociedade Brasileira de Ciência e Tecnologia de Alimentos, 2012-09-01) Lemos, Andréa dos Reis; Capriles, Vanessa Dias [UNIFESP]; Pinto e Silva, Maria Elisabeth Machado; Arêas, José Alfredo Gomes; Universidade de São Paulo (USP); Universidade Federal de São Paulo (UNIFESP)At the present celiac disease has no known cure, and its only treatment is a strict lifelong adherence to a gluten-free diet. Cheese bread is a traditional Brazilian product and a safe option for celiacs. However, like other gluten-free breads, it has inherent low levels of fibers and minerals. The objective of this study was to evaluate the effect of incorporation of whole amaranth flour on the physical properties and nutritional value of cheese bread. Amaranth flour was incorporated at 10, 15, and 20% proportions in different formulations. The increasing amaranth levels darkened the product, reduced specific volume, and increased compression force. Ten percent amaranth-content cheese breads exhibited slight differences in physical properties compared with the controls. These results demonstrated the possibility of incorporating 10% of whole amaranth flour in the formulation of cheese bread resulting in a product with higher dietary fiber and iron contents and the same level of acceptance as that of the conventional formulation. The aim of this approach is to increase the availability of gluten-free bakery products with added nutritional value contributing to increase the variety of the diet of celiac patients.
- ItemSomente MetadadadosImpacto do exercício físico nos marcadores bioquímicos de remodelação óssea e homeostase mineral em crianças e adolescentes com doença celíaca obedientes à dieta sem glúten(Universidade Federal de São Paulo (UNIFESP), 2014-05-30) Damiati, Rosa Amelia [UNIFESP]; Sdepanian, Vera Lucia Sdepanian [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)Objective: Assess the effects of physical exercise on biochemical markers of bone remodeling and mineral homeostasis in children and adolescents with celiac disease who compliance with gluten-free diet. Methods: We evaluated 24 patients with a mean age of 10.4 (2.6) years, 11 male, with celiac disease in obedience to the gluten free diet for over a year. All patients received supplemental calcium and vitamin D, aiming at achieving the recommendations of the RDA for age. The patients were divided into two groups: one group (n = 9) performed exercise of moderate impact four times a week for three months; another group did not perform physical exercise. Serum measurements were performed at baseline and after three months of bone formation markers P1nP and CTx bone resorption, 25OHD, intact parathyroid hormone, ionized calcium, phosphorus, magnesium, alkaline phosphatase, creatinine, albumin and urinary calcium. Results: After 3 months of exercise, the children had a mean concentration of the bone formation marker P1nP greater (p = 0,004) and higher 25OHD (p = 0,004) than those who did not engage in physical exercise, whereas adolescents did not show these differences . As for CTx and other biochemical markers of bone metabolism, there was no difference after 3 months of exercise in children and adolescents. In the group that did exercise, there was a correlation between P1nP before and after exercise (r = 0752, p = 0.020). Conclusions: The concentrations of the bone formation marker P1nP and 25OHD were higher after completion of exercise in children.
- ItemAcesso aberto (Open Access)Neurological manifestations of celiac disease(Academia Brasileira de Neurologia - ABNEURO, 2004-12-01) Siqueira Neto, José Ibiapina; Costa, Ana Carolina Leite Vieira; Magalhães, Francisco George; Silva, Gisele Sampaio [UNIFESP]; Federal University of Ceará Department of Internal Medicine; Federal University of Ceará Hospital Universitário Walter; Universidade Federal de São Paulo (UNIFESP)Celiac disease (CD/ Nontropicalsprue, gluten-sensitive enteropathy) is a malabsortive condition in which an allergic reaction to the cereal grain-protein gluten (present in wheat, rye and barley) causes small intestine mucosal injury. The onset is in the first four decades of life, with a female to male ratio of 2:1. It may be associated with a wide spectrum of neurological manifestations including cerebellar ataxia, epileptic seizures, dementia, neuropathy, myopathy and multifocal leucoencephalopathy. We report three patients with neurological manifestations related with CD: one with cerebellar ataxia, one with epilepsy and one with cognitive impairment. The diagnosis of CD was confirmed by serologic tests (antiendomysial and antigliadin antibodies) and biopsy of the small intestine. In two patients the neurological symptoms preceded the gastrointestinal abnormalities and in all of them gluten restriction failed to improve the neurological disability. Conclusion: CD should be ruled out in the differential diagnosis of neurological dysfunction of unknown cause, including ataxia, epilepsy and dementia. A gluten free diet, the mainstay of treatment, failed to improve the neurological disability.
- ItemSomente MetadadadosPrevalência da predisposição genética para doença celíaca nos doadores de sangue em São Paulo-Brasil(Universidade Federal de São Paulo (UNIFESP), 2014-05-30) Yoshida, Janaina Guilhem Muniz [UNIFESP]; Fagundes Neto, Ulysses Fagundes Neto [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)Background: Celiac disease (CD) is an immune-mediated enteropathy caused by a permanent intolerance induced by gluten, which is expressed by T-cell mediated enteropathy, and has a high prevalence in the general population. There is evidence of strong genetic predisposition to CD. Objective: To determine the prevalence of genetic markers HLA-DQ2 and HLA-DQ8 in blood donors from São Paulo and to measure human recombinant tissue transglutaminase antibody class IgA in those blood donors with HLA-DQ2 and HLA-DQ8 positive. Methods: A total of 404 blood donors from São Paulo city and Jundiaí were included in the study and signed the informed consent form. Informed regarding about diarrhea, constipation and abdominal pain in the last 3 months were also colleted. The determination of the HLADQ2 and HLADQ8 alleles was performed by PCR in all participants and human recombinant tissue transglutaminase antibody class IgA was measured only in blood donors who had DQ2 and/or DQ8 positive. Results: The HLADQ2 and/or HLADQ8 were positive in 49% (198/404) of subjects, and 11 (5%) of them were positive to human tissue transglutaminase test. Conclusion: We conclude that the prevalence of genetic markers for CD, HLA-DQ2 and HLA-DQ8, in blood donors from São Paulo, was high and similar to that found in Europe. These findings show that the prevalence of CD should not be rare in our country, but underdiagnosed.