Navegando por Palavras-chave "Raynaud s phenomenon"

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    Tratamento de pacientes com úlceras isquêmicas secundárias à esclerose sistêmica com N-acetilcisteína endovenosa
    (Sociedade Brasileira de Reumatologia, 2006-04-01) Kayser, Cristiane [UNIFESP]; Luz, Karine Rodrigues da [UNIFESP]; Rocha, Livanio Ferreira da [UNIFESP]; Andrade, Luiz Eduardo Coelho [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    The repetitive ischemic-reperfusion episodes in patients with systemic sclerosis (SSc) cause an increase in free radical activity, which may be implicated in the inflammatory and vascular lesions observed in this illness. Endovenous N-acetylicysteine is a potent anti-oxidant agent and might be beneficial to the treatment of vascular events in SSc. This communication reports on the use of endovenous N-acetylcysteine in three SSc patients with active ulcers in fingers and toes. At baseline, two patients presented two finger ulcers each, and a third patient had three ulcers in the toes. All patients presented a decrease in the dimensions of at least one ulcer. Two patients presented complete healing of one ulcer. These preliminary results suggest that endovenous N-acetylcysteine may be an efficient therapeutic option for extremity ulcers in SSc patients and support future randomized double blind placebo-controlled trials.