Navegando por Palavras-chave "Proton Pump Inhibitors"

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    Avaliação do uso contínuo de inibidores da bomba de prótons na biodisponibilidade de Fe, Ca total e ionizável, Zn, Mg, Cu e K
    (Universidade Federal de São Paulo (UNIFESP), 2021) Brito, Andrea Santana De [UNIFESP]; Nascimento, Angerson Nogueira do [UNIFESP]; Universidade Federal de São Paulo
    Many studies have shown a relationship between the prolonged use of proton pump inhibitors and the decrease in the bioavailability of several minerals and vitamins, bringing risks to patients using this class of drugs, however, certain relationships are not established. Therefore, this work aimed to evaluate the continuous use of proton pump inhibitors in the bioavailability of Fe, total and ionizable Ca, Zn, Mg, Cu and K. Wistar rats, recently weaned, weighing approximately 200 g, stored in appropriate cage with controlled temperature and humidity. The animals were organized in 2 groups (control and treated) and in subgroups according to the treatment time (10, 30 and 60 days), each subgroup containing 6 rats. The groups were kept at room temperature, with 12-hour cycles (light / dark), under a continuous flow of air; they received feed and water ad libitum, remaining in the same cage until the end of the study according to previous research. Six hours of fasting was performed during the day, immediately before the start of the daily omeprazole administration protocol. The animals at the end of each treatment period were euthanized, their blood and organs collected. Laboratory analysis of physiological (weight), biochemical and hematological parameters and determination of elements using ICP-MS was performed. The results were documented, analyzed and compared. The analyzes were evaluated statistically according to the analysis of variance method (ANOVA) with one and two evaluation criteria. Comparisons were made using the Tukey test. In all analyzes performed, the differences were considered significant when p˂ 0.05. In conjunction with the analysis of variance, effects size was used to examine the difference in means. The results found in this study confirmed that omeprazole may decrease some nutrients present in the diet of rats such as Fe and may cause hematological variations such as those found in hematological cell values such as leukocytes: monocytes, lymphocytes, neutrophils, in addition to decreasing hemoglobin and also affect the platelet count. These hematological changes may suggest a decrease in the immunity of the rats and in blood clotting and anemia.
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    Estudo clínico-molecular de pacientes com hipomagnesemia secundária ao uso crônico de inibidor de bomba de prótons
    (Universidade Federal de São Paulo (UNIFESP), 2017-01-31) Santos, Livia Marcela dos [UNIFESP]; Silva, Magnus Regios Dias da [UNIFESP]; http://lattes.cnpq.br/2598816440086436; http://lattes.cnpq.br/2305144569495023; Universidade Federal de São Paulo (UNIFESP)
    Purpose: Magnesium is an important electrolyte for all cell functions and its imbalance may lead to a large spectrum of diseases. Clinical case of hypomagnesemia diagnosed at the emergency due to chronic use of Proton Pump Inhibitor (PPI), which were excluded other magnesium deficiency causes. PPIs are drugs widely used in medical practice, and many cases of PPIs causing hypomagnesemia have been described. Our aim was to diagnosis and monitor the clinical and electrolyte findings during recovery from hypomagnesemia. Results: A female using omeprazole for 10 years presented with arrhythmia and severe hypomagnesemia. Laboratory tests revealed magnesium 0.6 mg/dL (NR: 1.5 to 2.5 mg/dL), calcium 7.3 mg/dL (NR: 8.5 to 10.2 mg/dL), parathyroid hormone (PTH) 13.3 pg/mL (NR: 15 to 65 pg/mL), and low urinary magnesium excretion. Her electrocardiography test disclosed typical prolonged QT interval and U waves. We discuss differential diagnoses, pathophysiology, and the reversibility of symptoms after effective treatment. Conclusion: We emphasize that even in mostly asymptomatic very long¬term PPI users, one can go to life-threatening arrhythmias.