Navegando por Palavras-chave "Povidona-iodo"

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    Evaluation of effectiveness of 10% polyvinylpyrrolidone-iodine solution against infections in wire and pin holes for Ilizarov external fixators
    (Associação Paulista de Medicina - APM, 2005-03-01) Camilo, Adelina Morais [UNIFESP]; Bongiovanni, José Carlos [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Orthopedics and Traumatology Center of Jundiaí
    CONTEXT AND OBJECTIVE: Superficial infection at wire and pin insertions in the skin is a frequent disorder among patients utilizing the Ilizarov method. The objective of this study was to evaluate the effectiveness of daily topical application of 10% polyvinylpyrrolidone-iodine solution against infections of the holes for Kirschner wires and Schanz pins among patients using Ilizarov external fixators, in comparison with cleaning these holes only with 0.9% sterile physiological saline solution. DESIGN AND SETTING: Controlled randomized clinical trial, in the Orthopedics and Traumatology Outpatient Clinic, Hospital São Paulo, and Orthopedics and Traumatology Center of Jundiaí. METHODS: 30 patients were treated using the Ilizarov technique: 15 were instructed to apply 0.9% physiological saline dressing on the wire and pin insertions and 15 to apply 0.9% physiological saline plus 10% polyvinylpyrrolidone-iodine. Patients were evaluated at outpatient return visits for identification of signs and symptoms of superficial infection at wire and pin insertion sites. Samples were collected from cases of purulent exudate secretion, for culturing and clinical tests. RESULTS: The chi-squared and Fischer exact tests were applied, but no statistically significant association between the intervention of topical polyvinylpyrrolidone-iodine solution and the prevention of infections at wire and pin insertions could be found. CONCLUSIONS: Topical 10% polyvinylpyrrolidone-iodine solution applied daily to Kirschner wire and Schanz pin insertions did not reduce the incidence of superficial infection at these holes, in comparison with mechanical removal of dirt using 0.9% physiological saline solution.
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    PVP-I aquoso em almotolias: estudo da frequência de contaminação
    (Universidade Federal de São Paulo (UNIFESP), 1994) Peterlini, Maria Angélica Sorgini [UNIFESP]; Cardo, Denise Mary [UNIFESP]
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    Toxicidade córneo-conjuntival do colírio de iodo-povidona: estudo experimental
    (Conselho Brasileiro de Oftalmologia, 2003-06-01) Santos, Namir Clementino [UNIFESP]; Sousa, Luciene Barbosa de [UNIFESP]; Freitas, Denise de [UNIFESP]; Rigueiro, Moacyr Pezati [UNIFESP]; Scarpi, Marinho Jorge [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    PURPOSE: To evaluate ocular toxicity of povidone-iodine eye drops at a concentration of 2.5% and 0.5% and to investigate the effects on corneal epithelial wound healing and histopathological alterations. METHODS: Each group (PVP-I 2.5% and 0.5%) consisted of 20 rabbits. A central circular corneal epithelial defect of 6.5 mm diameter was created and the povidone-iodine eyedrops (2.5% and 0.5) instilled in the right eye and distilled water in the left eye (control) of each rabbit, every hour, during 3 days. Biomicroscopical examinations were performed every day, focussing on the corneoconjunctival surface and the diameter of the lesion, using fluoresceine eye drops, photodocumentation, and a computerized image analyzer. After the third day the rabbits were sacrified and the excised corneas histopathologically evaluated. Statistical evaluation was performed using Friedman, Mann-Witney, Wilcoxon, Fisher and Chi-squared tests. RESULTS: Povidone-iodine eye drops, at a concentration of 2.5%, caused an increase in the wound healing time (p= 0.087) and conjuntivitis in 100% of the eyes with mucous secretion in 80%, punctate ceratitis in 40%, and discrete stromal edema in 10% of the cases. The histopathological examination showed corneal ulcers and vacuolic degeneration of the endothelial layer in 100%, as well as an inflammatory infiltrate with eosinophils in 80% of the cases. The eyes treated with povidone-iodine eye drops at a concentration of 0.5% and the control eyes showed complete epithelial wound healing after 72 hours, and histopathologically normal epithelization. Only in one case, a discrete perilimbar leucocytic infiltrate was observed. CONCLUSION: The ocular toxicity of povidone-iodine eye drops is concentration-dependent. The use of the eye drop at a concentration of 2.5% is not adequate for daily and repetitive use. In contrast, at a concentration of 0.5% no toxicity was observed.