Navegando por Palavras-chave "Phenytoin"

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    Avaliação do efeito da fenitoína (5,5-difenil-2-4- imidazolidione, sódio) na cicatrização cutânea da excisão de nevos melanocíticos na face e no dorso do tórax
    (Universidade Federal de São Paulo (UNIFESP), 2009-05-25) Pereira, Carlos Augusto Zanardini [UNIFESP]; Alchorne, Alice de Oliveira de Avelar [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    This study aims to evaluate the effect of topical use of phenytoin in healing of skin wounds. A systemic therapy with phenytoin have anticonvulsant activity, and the topical use action is to accelerate the healing of skin wounds. This study evaluated 100 patients each with 2 wounds resulting from excision of lesions of melanocytic nevi, 50 patients with lesions on the face and 50 whith back injuries in the chest, total of 200 lesions excised with punch modified. During treatment the patient received phenytoin to 0.5% in the cream and cream base (control), to make the dressing daily. The follow up of patients was carried out from 7, 14, 21 and 60 days, where the following parameters were evaluated: bleeding, exudate, erythema at the edge of the wound, infection, presence of hypertrophic granulation tissue, healing time, intensity of epithelialization, the wound area, the shape and area of the scar, possible adverse reactions and cosmetic outcome. The patients were compared in age, weight, height, phototype, histological type of lesion. The phenytoin showed better therapeutic and cosmetic results compared with the cream base (control). The phenytoin is a drug of low cost, which accelerates the healing of skin wounds.
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    Síndrome da Luva Púrpura: principais intervenções preventivas e terapêuticas de enfermagem
    (Escola Paulista de Enfermagem, Universidade Federal de São Paulo (UNIFESP), 2007-06-01) Kusahara, Denise Miyuki [UNIFESP]; Rocha, Patrícia Kuerten; Peterlini, Maria Angélica Sorgini [UNIFESP]; Pedreira, Mavilde da Luz Gonçalves [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Universidade Federal de Santa Catarina Programa de Pós-Graduação em Enfermagem
    The Purple Glove Syndrome, complication related to the administration of phenytoin through peripheral intravenous catheters, is characterized for the development of injuries in the site of catheter placement. Injuries range from phlebitis to local necrosis, being possible to identify in most severe cases, the development of the compartmental syndrome and its severe consequences.To describe the Purple Glove Syndrome and the main preventive and therapeutic nursing care. A literature search on the topic was conducted. This search provided enough information to characterize the purple glove syndrome as well as to identify main nursing interventions for the prevention and management of the syndrome.
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    Tratamento da Eclâmpsia: Estudo Comparativo entre o Sulfato de Magnésio e a Fenitoína
    (Federação Brasileira das Sociedades de Ginecologia e Obstetrícia, 2000-10-01) Valadares Neto, João de Deus; Bertini, Anna Maria [UNIFESP]; Taborda, Wladimir [UNIFESP]; Parente, Joaquim Vaz; Universidade Federal do Piauí Maternidade Dona Evangelina Rosa Disciplina de Obstetrícia; Universidade Federal de São Paulo (UNIFESP)
    Purpose: to compare the efficiency between magnesium sulfate and phenytoin in the control of convulsions in patients with eclampsia and to evaluate the effects of magnesium sulfate and phenytoin on the maternal and perinatal prognosis in patients with eclampsia. Methods: this is a prospective, randomized and controlled study in which the results obtained with the use of anticonvulsive treatment in 77 women with eclampsia, treated with either magnesium sulfate or phenytoin, were analyzed comparatively. The drugs which were used in both therapeutic schemes were distributed in a one to one ratio, in randomly numbered boxes which presented similar characteristics. When a patient was admitted, a box was opened and its contents were given to the patient. Results: in the group whose patients were treated with magnesium sulfate, 19.5% had recurrent convulsions while in the group whose patients used phenytoin, 36.1% had new crises (p<0,05). The patients who were treated with magnesium sulfate showed a greater prevalence of postpartum hemorrhage (14,7%) than those to whom phenytoin was administered (2.7%) (p<0.05). In relation to the newborns, 17.0% of the group from mothers treated with magnesium sulfate presented respiratory distress as opposed to the group of newborns from mothers treated with phenytoin (11.8%), (p> 0,05). Conclusion: magnesium sulfate is shown to be more efficient than phenytoin in the control and the prevention of convulsions in patients with eclampsia. However, its utilization showed a higher prevalence of postpartum hemorrhage and respiratory distress. Phenytoin should be used in cases where the use of magnesium sulfate is contraindicated.