Navegando por Palavras-chave "Paralisia bulbar progressiva"

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    Histórico da atividade física habitual dos pacientes com esclerose lateral amiotrófica
    (Universidade Federal de São Paulo (UNIFESP), 2016-03-30) Pereira, Roberto Dias Batista [UNIFESP]; Oliveira, Acary Souza Bulle [UNIFESP]; http://lattes.cnpq.br/3911841387107665; http://lattes.cnpq.br/4044980759880943; Universidade Federal de São Paulo (UNIFESP)
    Objective: To identify the historical profile of habitual physical activity in people with Motor Neurone Disease / Amyotrophic Lateral Sclerosis (MND/ALS) and compared to healthy subjects. Methods: 202 subjects were selected, these 71 diagnosed with ALS, 18 with Paralysis Progressive Bulbar (PBP) and 8 with Family ELA (FAMILY), of the remaining 105 consisted of healthy individuals as a control group. The patients underwent medical evaluation, physiotherapy and all participants responded to the questionnaire on habitual physical activity Baecke, for periods from 10 to 20 years, 21 to 30 years, the last 12 months; and related will MND/ALS the last two years before the first symptom. Results: When comparing the scores of the questionnaire was shown that patients with MND/ALS, regardless of the type of disease evolution, performed more habitual physical activity (HPA) from 10 to 20 years, especially the occupational physical activity (OPA), and OPA from 21 to 30 years compared with the control group. The OPA more strongly related with the development of the disease was the Farmer (30% of patients), regardless of subtype classification, in the period from 10 to 20 years old. Earlier detection of initial symptoms was more related to HPA more intense, between 21 and 30 years, in patients with Family ALS, and OPA more intense in the last two years before the appearance of symptoms. Greater physical activity in leisure and locomotion (LLA) in the period from 10 to 20 years, especially men, was related to the need to use a wheelchair later. The HPA most intense the last 12 months was related to an earlier need to use wheelchair and installation of noninvasive mechanical ventilation and percutaneous endoscopic gastrostomy. Conclusions: The history of habitual physical activity most intense in patients with MND/ALS, especially OPA, has a direct bearing on the development of the disease, in anticipation of need for special care.
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    Modulação autonômica cardíaca e sua relação com a capacidade pulmonar em indivíduos com paralisia bulbar progressiva e esclerose lateral amiotrófica
    (Universidade Federal de São Paulo (UNIFESP), 2018-08-29) Pimentel, Renata Martins [UNIFESP]; Ferreira, Celso [UNIFESP]; Abreu, Luiz Carlos de [UNIFESP]; http://lattes.cnpq.br/6796970691432850; Cardiac autonomic modulation and pulmonary capacity in individuals with amyotrophic lateral sclerosis and progressive bulbar palsy; http://lattes.cnpq.br/6851397444757156; http://lattes.cnpq.br/1417020520652193; Universidade Federal de São Paulo (UNIFESP)
    Introduction: Motor neuron diseases (MND), characterized by amyotrophic lateral sclerosis (ALS) and progressive bulbar palsy (PBP), is defined by progressive, irreversible and incapacitating motor paralysis with survival from two to five years after the beginning of the symptomatology. Death is traditionally related to ventilatory impairment and / or systemic complications, although unexplained sudden death is not infrequent. Considering that DNM may compromise other systems, including the autonomic nervous system, proposed to evaluate the cardiac autonomic modulation and relation with pulmonary capacity in patients with ALS and PBP. Method: A total of 91 patients were analyzed: 58 with diagnosis of Amyotrophic Lateral Sclerosis and 33 with Progressive Bulbar Palsy. Clinical diagnoses were obtained from medical observations; the data collection and data were obtained from the Research Section of Neuromuscular Diseases of UNIFESPEPM. In these patients, heart rate variability and spirometry were performed. Thus, they were classified according to Forced Vital Capacity (FVC) with values greater than and less than 50%. In addition, subsequently the statistical analysis. Results: Patients with ALS and PBP presented significant differences in linear indices SDNN, pNN50, RMSSD when compared to normal values; there was no significant difference between the PBP and ALS groups in the linear indices. However, in the nonlinear indices, it was observed that the α1 index was higher in the ALS group when compared to PBP. However, when compared to FVC, there was a lower value in the pNN50 index, only in the PBP group, especially in those patients requiring noninvasive ventilation. Conclusion: There was a decrease in global variability and parasympathetic hypoactivity in relation to normality; strong shortterm fractal correlation in the ELA group in relation to PBP group; lower parasympathetic activity in patients with noninvasive mechanical ventilation.