Navegando por Palavras-chave "Obesity/Treatment"

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    Avaliação da influência da derivação gástrica em Y-de-Roux na função sexual feminina em obesas – Um estudo prospectivo
    (Universidade Federal de São Paulo (UNIFESP), 2020-04-30) Menezes, Mariano De Almeida [UNIFESP]; Fernandes, Fernando Augusto Mardiros Herbella [UNIFESP]; Universidade Federal de São Paulo
    Introduction: Obesity can affect female sexual function and lead to hyperandrogenia. This study aims to evaluate female sexual function and androgenic profile in obese women after Gastric Bypass (GB). Methods: Forty obese women with a mean age of 34 years were prospectively studied. Those with diabetes mellitus, psychiatric diseases, under medication that could interfere with sexual function and history of pelvic surgery were excluded. All patients underwent laparoscopic GB. Total and free testosterone, androstenedione and dehydroepiandrosterone (DHEA) and the application of a female sexual function questionnaire (QS-F) were evaluated, preoperatively and at 6 and 12 months after the operation. Results: Preoperative incidence of sexual dysfunction was 10% and hyperandrogenia was present in 40% of the individuals. After GB, there was an improvement in female sexual function (p = 0,02), mainly related to the improvement of desire and sexual interest (p = 0,002), and sexual comfort (p = 0,03) and there was not case of sexual dysfunction 12 months after the operation. The improvement of the sexual function did not happen in first six months of the surgery (QS-F 77.5 – 78.8 points, p = 0.812), however there was a decrease of the free testosterone levels (0.49 – 0.33 ng/dl, p < 0.001) and androstenedione (2.0 – 1.3 ng/dl, p < 0.001), but there was not alterations of de DHEA levels (3.4 – 3.2 ng/dl, p = 0.120). At 1 year of follow-up, there was a reduction in the incidence of hyperandrogenia (40% – 7.9%, p < 0.001), free testosterone levels, androstenedione and an increase in DHEA levels. Total testosterone levels did not change significantly. There was not statistic correlation between androgen levels and female sexual function, as also between the anthropometrics parameters and sexual function. Loss of excess BMI was 46% at 6 months and 85% at 1 year. Conclusion: Female sexual function in obese women improves in patients undergoing GB, especially in desire, interest and sexual comfort, and this happens after 6 months of surgery and may be related to improvement of androgenic profile, mainly improvement of DHEA, and loss of excess BMI of these patients.