Navegando por Palavras-chave "Neoplasia De Meninges"

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    Tumor miofibroblástico meníngeo, um desafio diagnóstico
    (Universidade Federal de São Paulo (UNIFESP), 2019-12-18) Peruzzo, Barbara Giovanna [UNIFESP]; Vilanova, Luiz Celso Pereira [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    A 19 years old male patient, with onset of progressive headache 7 years ago, as well as visual and hearing loss, and epilepsy. Physical examination showed proptosis and optic atrophy. Brain magnetic resonance imaging (MRI) revealed diffuse meningeal thickening and enhancement with some nodular areas, edema of the parenchyma and occlusion of the right transverse and sigmoid sinuses. Cerebrospinal fluid (CSF) identified lympho-mononuclear pleocytosis and hyperproteinorrachia. Collagenosis and vasculitis laboratory tests were normal. Cerebral and meningeal biopsy revealed myofibroblast proliferation and lymphoplasmacytic infiltration, without immunohistochemical expression for IgG4 (positivity less than 5%), which suggest the diagnosis of inflammatory myofibroblastic meningeal tumor. The objective of this study is to describe a clinical case that is hard to diagnose, with a long time from onset of symptoms to a diagnostic definition, where definitive diagnosis was possible only after the third meningeal biopsy.