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- ItemSomente MetadadadosNew Insights on the Pathophysiology of Inspiratory Flow Limitation During Sleep(Springer, 2015-06-01) Godoy, Luciana B. M. de [UNIFESP]; Palombini, Luciana O. [UNIFESP]; Martinho Haddad, Fernanda L. [UNIFESP]; Rapoport, David M.; Vidigal, Tatiana de Aguiar [UNIFESP]; Klichouvicz, Priscila Calixto [UNIFESP]; Tufik, Sergio [UNIFESP]; Togeiro, Sonia M. [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); NYUInspiratory flow limitation (IFL) is defined as a flattened shape of inspiratory airflow contour detected by nasal cannula pressure during sleep and can indicate increased upper airway resistance especially in mild sleep-related breathing disorders (SRBD). the objective of this study was to investigate the association between upper airway abnormalities and IFL in patients with mild SRBD.This study was derived from a general population study consisting of selected individuals with apnea-hypopnea index (AHI) below 5 events/h of sleep, (no obstructive sleep apnea group) and individuals with AHI between 5 and 15 events/h (mild obstructive sleep apnea group). A total of 754 individuals were divided into four groups: group 1: AHI < 5/h and < 30 % of total sleep time (TST) with IFL (515 individuals), group 2: AHI < 5/h and > 30 % of TST with IFL (46 individuals), group 3: AHI: 5-15/h and < 30 % of TST with IFL (168 individuals), and group 4: AHI: 5-15/h and > 30 % of TST with IFL (25 individuals).Individuals with complains of oral breathing demonstrated a risk 2.7-fold larger of being group 4 compared with group 3. Abnormal nasal structure increased the chances of being in group 4 3.2-fold in comparison to group 1. Individuals with voluminous lateral wall demonstrated a risk 4.2-fold larger of being group 4 compared with group 3.More than 30 % of TST with IFL detected in sleep studies was associated with nasal and palatal anatomical abnormalities in mild SRBD patients.
- ItemSomente MetadadadosObstructive Sleep Apnea Syndrome in the São Paulo Epidemiologic Sleep Study(Elsevier B.V., 2010-05-01) Tufik, Sergio [UNIFESP]; Santos-Silva, Rogerio [UNIFESP]; Taddei, Jose Augusto [UNIFESP]; Azeredo Bittencourt, Lia Rita [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)Objective: To estimate the prevalence of Obstructive Sleep Apnea Syndrome (OSAS), using current clinical and epidemiological techniques, among the adult population of São Paulo, Brazil.Methods: This population-based survey used a probabilistic three-stage cluster sample of São Paulo inhabitant S to represent the population according to gender, age (20-80 years), and socio-economic status. Face-to-face interviews and in-lab full-night polysomnographies using a nasal cannula were performed. the prevalence of OSAS was determined according to the criteria of the most recent International Classification of Sleep Disorders (ICDS-2) from American Academy of Sleep Medicine (2005).Results: A total of 1042 volunteers underwent polysomnography (refusal rate = 5.4%). the mean age +/- SD was 42 +/- 14 years; 55% were women and 60% had a body mass index > 25 kg/m(2). OSAS was observed in 32.8% of the participants (95% CI, 29.6-36.3). A multivariate logistic regression model identified several independent and strong associations for the presence of OSAS: men had greater association than women (OR = 4.1; 95% Cl, 2.9-5.8; P < 0.001) and obese individuals (OR = 10.5; 95% Cl, 7.1-15.7; P < 0.001) than individuals of normal weight. the adjusted association factor increased with age, reaching OR = 34.5 (95% Cl. 18.5-64.2: P < 0.001) for 60-80 year olds when compared to the 20-29 year old group. Low socio-economic status was a protective factor for men (OR = 0.4), but was an associated factor for women (OR = 2.4). Self-reported menopause explained this increased association (age adjusted OR = 2.1; 95% Cl, 1.4-3.9; P < 0.001), and it was more frequent in the lowest class (43.1%) than either middle class (26.1%) or upper class (27.8%) women.Conclusions: This study is the first apnea survey of a large metropolitan area in South America identifying a higher prevalence of OSAS than found in other epidemiological studies. This can be explained by the use of the probabilistic sampling process achieving a very low polysomnography refusal rate, the use of current techniques and clinical criteria, inclusion of older groups, and the higher prevalence of obesity in the studied population. (C) 2010 Elsevier B.V. All rights reserved.