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    Efeito da sinvastatina sobre a pressão arterial, metabolismo glicídico, metabolismo lipídico e função endotelial em ratos espontaneamente hipertensos tornados obesos
    (Universidade Federal de São Paulo (UNIFESP), 2018-01-18) Ferreira, Diego Faria Marques [UNIFESP]; Cesaretti, Mario Luis Ribeiro [UNIFESP]; http://lattes.cnpq.br/6026967513178490; http://lattes.cnpq.br/5770785379698382
    INTRODUCTION: Systemic arterial hypertension and obesity are associated with several comorbidities, such as diabetes and endothelial dysfunction. Simvastatin with its pleiotropic effects act on several systems (inflammation, release of vasodilation factors, among others) and show beneficial effects. OBJECTIVE: To evaluate the effects of simvastatin administration on glucose metabolism, lipid metabolism and vascular responsiveness in spontaneously hypertensive rats (SHR) made obese. METHODS: Spontaneous hipertensive rats male with 12 weeks of life were divided into 4 groups: control (SHR, n = 7), SHR + hyperlipidemic diet (SHR + HIPER, n = 5), SHR + simvastatin (n = 7) and group (SHR + HIPER + SINVA, n = 7). The hyperlipidic diet was administered from the weaning period and the dose of simvastatin was 10mg / kg / day, by gavage from the 13th to the 20th week. Body mass and caudal blood pressure were evaluated weekly. At the end of the study, the oral glucose tolerance test (TTGO), insulin tolerance test (TTI), lipid dosage, determination of vascular reactivity and left ventricular mass and epididymal fat were performed. RESULTS: The induction of obesity did not alter the parameters related to tail blood pressure and body weight, even when associated with simvastatin. As for glucose metabolism the administration of a hyperlipidic diet resulted in a significant increase of the area under the glucose curve. The vascular reactivity to acetylcholine, the SHR + SINVA group showed improvement in vasodilatation, whereas the other groups, when the hyperlipidic diet was associated, their effects were abolished. In the dosage of triglycerides, the groups treated with simvastatin obtained a significant reduction in their values, as well as in total cholesterol (TC), low density lipoprotein (LDL) dosage, very low density lipoprotein (VLDL). Regarding the dosage of high density lipoprotein (HDL), the association of pharmacological treatment together with the induction of obesity caused a significant increase in their values. The hyperlipidic diet caused the groups to have a significant increase in the weight of epididymal fat. CONCLUSION: Simvastatin treatment was effective in determining improvement in the endothelial function of SHR rats, but not in SHR + HIPER + SINVA. The increase of the epididymal fat induced by the hyperlipidic diet despite the improvement of the parameters of lipid metabolism, prevented the benefits induced by simvastatin on endothelial function.