Navegando por Palavras-chave "Esteroide 17-alfa-Hidroxilase"

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    Análise da relação entre polimorfismo do gene cyp17 e sintomas vasomotores em mulheres na pós-menopausa com terapia estrogênica
    (Universidade Federal de São Paulo (UNIFESP), 2011-02-22) Nogueira Júnior, Roberto Cesar [UNIFESP]; Soares Júnior, José Maria [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    To evaluate the influence of CYP17 polymorphism on menopausal symptoms after estrogen treatment. Design: A total of 130 women were recruited, but only 100 of these were selected according to inclusion and exclusion criteria, and they were treated with 0.3mg/day of conjugated equine estrogens. One year later the study was completed with 70 women. The analysis of the Kuppermann Menopausal Index (KMI) symptoms was made with information provided by the patients on daily diary cards. Blood samples were analyzed and the women were divided into two groups based on the CYP17, 5´ untranslated region: GA (wild-type homozygote and heterozygote) and GB (mutated homozygote). Results: The values of KMI were similar in both groups (GA = 31.11 ± 9.95 and GB= 30.39 ± 7.74) at baseline. The symptoms in both groups decreased after one year of treatment when compared to those at baseline. The improvement rate was approximately 27.09% and 32.18%, in GA and GB, respectively. The levels of estrogen after treatment were higher in both groups in comparison with the baseline values. The testosterone level rose in GB with the one-year treatment (0.48 ± 0.16) reaching a higher level than the GA level after treatment. The SHBG level showed a significant increase after the one-year treatment in GB surpassing both the baseline and the after treatment values of GA (p<0.01). Conclusion: Our data suggest CYP17 polymorphism did not influence the unopposed estrogen during the one-year treatment. The extra production of estrogen and androgen may have been countered by the elevation of SBHG.Key words: Polymorphism; CYP17; estrogen; hot flashes.
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    Análise do polimorfismo do gene CYP 17 como fator relacionado ao desenvolvimento do leiomioma uterino
    (Universidade Federal de São Paulo (UNIFESP), 2009-09-24) Vieira, Lucinda Coelho Esperança [UNIFESP]; Girão, Manoel João Batista Castello [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Objective: Uterine leiomyoma is the most common pelvic tumor in women of reproductive age. It has been well established that endogenous sex hormones are involved in the pathogenesis of the disease, and polymorphisms in genes encoding for enzymes that act in the steroid hormones metabolism, as the CYP17, may therefore play a role in the genesis of fibroids. Variations in this gene have been thought to be candidates influencing the susceptibility to hormone-related diseases. A single nucleotide polymorphism (T→C) [rs1042386] in the promoter region of CYP17 is speculated to alter its transcription. The present study was conducted to investigate the association between this polymorphism and the presence of uterine leiomyoma in Brazilian women. Methods: Genotyping of the CYP17 was performed in 121 uterine fibroid patients and 120 unaffected women using polymerase chain reaction and restriction fragment length polymorphism analysis. Results: No significant difference in the CYP17 genotype distribution was noted between cases and controls (p=0.165) Conclusion: These findings suggest that the CYP17 gene polymorphism studied is unlikely to be associated with risk for uterine leiomyoma in Brazilian women.
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    Prevalencia de cistos mamarios na populacao geral feminina e sua correlacao com o polimorfismo do gene CYP 17
    (Universidade Federal de São Paulo (UNIFESP), 2010) Pinotti, Solange Cristina Tote Franco [UNIFESP]