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- ItemAcesso aberto (Open Access)O estadiamento TNM do carcinoma de células renais deve ser modificado novamente ?(Associação Médica Brasileira, 2003-01-01) Dall'Oglio, Marcos Francisco [UNIFESP]; Srougi, Miguel [UNIFESP]; Nesrallah, Luciano [UNIFESP]; Leite, Kátia Ramos Moreira [UNIFESP]; Hering, Flávio [UNIFESP]; Bomfim, Alexandre de Campos [UNIFESP]; Sanudo, Adriana [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)OBJECTIVE: The behavior of the renal cells carcinoma stage PT1 is not completely clarified. We studied the presence of factors after prognostics and tumoral size in the recurrence of survival of the sporadic kidney carcinoma after surgical treatment. METHODS: 120 patients followed after nephrectomy had been revised retrospectively 93 PT1, 9 PT2, 11 PT3, 7 PT4, It was analyzed survival and recurrence of the disease inside of three groups of tumors: Group 1: < 4cm, group 2: 4-7cm and group 3: > 7cm, and the prognostics factors above-mentioned evaluated were nuclear degree, microvascular invasion, presence of committed ganglia and sarcomatous degeneration. RESULTS: The frequency of adverse prognostics factors increase as the tumor size increase. In the group 1, we had only four tumors of high degree and only one shown microvascular invasion that does not committed ganglia or sarcomatous degeneration. In group 2 there was 16 tumors of high degree, 4 sarcomatoses, two with positive microvascular invasion and two with positive ganglia. In group 3, was found 18 tumors of high degree, 15 with microvascular invasion and 7 with positive ganglia and 5 sarcomatoses. There was statistical significance in the specific cancer survival (p=0.002) and free of illness (p=0.0002) between the three groups. CONCLUSION: The evolution of tumors PT1 is distinct for lesser tumors of 4 cm and 4-7 cm fitting the subdivision of these two groups in T1a and T1b.
- ItemAcesso aberto (Open Access)Prognosis related to staging systems for chronic lymphocytic leukemia(Associação Paulista de Medicina - APM, 2000-07-06) Faria, José Roberto de; Oliveira, José Salvador Rodrigues de [UNIFESP]; Faria, Rosa Malena Delbone de; Silva, Maria Regina Regis; Goihman, Samuel [UNIFESP]; Yamamoto, Mihoko [UNIFESP]; Kerbauy, José [UNIFESP]; Universidade de Alfenas Division of Hematology; Universidade Federal de São Paulo (UNIFESP)CONTEXT: Chronic lymphocytic leukemia (CLL) is a clonal lymphoproliferative disorder, characterized by B lymphocytic proliferation. CLL is the most frequent adult leukemia in Western countries, accounting for 25 to 30% of all white leukemic patients. OBJECTIVE: To evaluate clinical and staging characteristics in prognosis of chronic lymphocytic leukemia. DESIGN: Evaluation of clinical-staging data. SETTING: Universidade Federal de São Paulo (UNIFESP) - Escola Paulista de Medicina / Universidade de Alfenas. SAMPLE: 73 patients diagnosed from 1977 to 1994. MAIN MEASUREMENTS: Sex, ethnic origin, age, lymphadenopathy, splenomegaly, hepatomegaly, three or more areas of lymphoid enlargement, hemoglobin (g/dl), lymphocytes/mm³, Platelets/mm³ RESULTS: Mean survival of patients was 76 months, median age was 65 years, ranging from 33 to 87. Forty-four patients (60.3%) were male and 29 (39.7%) female. CONCLUSION: The Binet system determined a better prognosis than Rai.