Navegando por Palavras-chave "Disfunção Cognitiva"

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    Estudo da associação entre BDNF sérico e disfunção cognitiva em pacientes com lúpus eritematoso sistêmico
    (Universidade Federal de São Paulo (UNIFESP), 2020-02-07) Alessi, Helena [UNIFESP]; Barsottini, Orlando Graziani Povoas [UNIFESP]; Universidade Federal de São Paulo
    Objective: To investigate serum brain derived neurotrophic factor (BDNF) as a possible biomarker for cognitive dysfunction (CD) in a large systemic lupus erythematosus (SLE) cohort. Methods: We determined BDNF levels of 111 patients with SLE (48 with major neuropsychiatric manifestations, NPSLE, such as seizure, psychosis, myelitis, stroke, peripheral neuropathies, demyelinating syndrome, acute confusional state, aseptic meningitis, and central nervous system vasculitis) and 57 matched controls (CON). Data on cardiovascular comorbidities, medication use, autoantibodies profile, SLE disease activity (SLEDAI), and SLE damage index (SDI) were evaluated. All subjects underwent neuropsychological assessment for attention, verbal and visual memory, constructional praxis, processing speed, and executive functions. Anxiety (BAI) and depression (BDI) were assessed by questionnaires. CD was defined as 2 or more standard deviations below the normative value in three or more cognitive domains assessed. Clinical features and BDNF levels were evaluated by regression analyses. ROC curve analysis was used to determine the cut-off value. Results: CD was found in 46.8% of patients (34.9% of non-NPSLE and 62.5% of NPSLE cases). BDNF level was significantly lower in SLE patients (CON: 1,345.5 ng/ml ± 438.4, non-NPSLE: 800.4 ± 502.7, NPSLE: 779.7 ± 426.3, p<0.001), independently associated with SDI (B: -75.9, SE: 27.2, 95% CI: -129.8 – -22, p=0.006) and hypertension (B: -192.5, SE: 84.3, 95% CI: -359.7 – -25.3, p=0.024). There was no association between BDNF and CD. The cutoff value to differentiate patients and controls was 937.5 ng/ml, with a specificity of 67.9% and a sensitivity of 84.2%.Conclusion: SLE patients have lower levels of BDNF, independently of neuropsychiatric manifestations. BDNF is associated with SDI and hypertension, but not with CD, suggesting that it might be a biomarker for SLE- related damage rather than cognition.