Navegando por Palavras-chave "Corticospinal Tract"

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    Neuroimagem com utilização com sequência de tensor de difusão para avaliação da via piramidal em pacientes com ataxia espinocerebelar tipo 3
    (Universidade Federal de São Paulo (UNIFESP), 2020-10-29) Inada, Bruno Shigueo Yonekura [UNIFESP]; Pedroso, Jose Luiz [UNIFESP]; Universidade Federal de São Paulo
    Objective: Evaluate the pyramidal tract of patients with spinocerebellar ataxia type 3 and correlate with the scale for the assessment and rating of ataxia (SARA). Methods: This study used diffusion tensor imaging to access the pyramidal tract of 120 spinocerebellar ataxia type 3 patients from 2 different health centers: 29 patients from Ataxia outpatient clinic at UNIFESP hospital and 91 patients from Neurogenetic outpatient clinic at UNICAMP hospital that underwent a 1.5 Tesla and 3,0 Tesla magnetic resonance image, respectively. We selected 120 age and gender-matched healthy individuals. Fractional anisotropy, mean diffusivity, radiation diffusivity and axial diffusivity values were obtained and correlated with the scale for the assessment and rating of ataxia. Results: In group 1, a significant reduction was found only in the fractional anisotropy (FA) values in the pre-central gyrus bilaterally. In group 2 there was a significant reduction in the FA values and a significant increase in the values of mean diffusivity (MD), radial diffusivity (RD) and axial diffusivity (AD) in corticospinal tract, except for the MD and AD values in the right precentral gyrus and AD values in the left precentral gyrus, bilateral superior corona radiata and the right cerebral peduncle. Moderate negative correlation was found between the FA values on the entire length of the corticospinal tract of patients in group 2 and SARA, in addition to a moderate positive correlation between the values of MD and RD on the entire length of the corticospinal tract of patients in group 2 and SARA. Conclusions: we demonstrated the presence of a microstructural lesion in the pyramidal tract of SCA3 patients, which may explain the high frequency of pyramidal signs in these patients, in addition to the moderate correlation with the scale for the assessment and rating of ataxia (SARA). In addition, we observed that the alteration in the corticospinal tract occurs more sharply in the caudal segment (base of the bridge) than in the cranial segment (pre-central gyrus), which may suggest a “dying back” degeneration mechanism.