Navegando por Palavras-chave "Circadian Rhythm"

Agora exibindo 1 - 2 de 2
  • Imagem de Miniatura
    Item
    Acesso aberto (Open Access)
    O efeito da iluminação ambiental na atividade, no repouso e no nível de melatonina urinária de puérperas hospitalizadas.
    (Universidade Federal de São Paulo (UNIFESP), 2019-09-26) Volcov, Cristina Furtado [UNIFESP]; Coca, Kelly Pereira [UNIFESP]; Pinheiro, Eliana Moreira; http://lattes.cnpq.br/0313695891816024; http://lattes.cnpq.br/8167230363189115; http://lattes.cnpq.br/6547980567614545; Universidade Federal de São Paulo (UNIFESP)
    Introduction: Woman's organism undergoes physiological changes in the postpartum mediate. Changes on activity and rest may be increased by the need for exposure to artificial lighting at nighttime due to the care of the newborn. Objectives: To verify the effect of artificial ambient lighting on the activity, rest and urinary melatonin level of hospitalized postpartum women. Method: Pilot clinical trial with 21 postpartum women admitted to a rooming-in unit of a university hospital in São Paulo. Women with the following characteristics were included: aged ≥18 years, single pregnancy and ≥12 hours after delivery; without a history of psychiatric diseases, use of illicit drugs during pregnancy, thyroid disorders and/or sleep and night work in the last three years; whose child was born at term, healthy and was breastfeeding. Excluded were those with: blindness, obstetric complications and under use of medications (beta-blocker, diuretics, corticosteroids and/or central nervous system depressors) in the last 72 hours. The women were randomized to control and experimental groups. The intervention consisted on the exposure of the women to long wavelength light illumination during nighttime when they were hospitalized in a specific room with controlled environment lighting. The experimental room was prepared for exposure to the experiment’s artificial lighting. Women's characterization data were identified to assess group homogeneity by interview. The variables related to activity and rest were obtained from actimeter records, and the level of 6-sulfatoxymelatonin was identified by the Elisa Method after 24-hour urine collecting. Results: The control and experimental groups studied were homogeneous. Women in the experimental group had longer resting time at 24 hours; however, the total mean activity and rest were not statistically significant when compared to those in the control group (p=0.61 and p=0.57 respectively). Regarding the level of 6-sulfatoxymelatonin, the mean excreted was higher during the daytime in the experimental group and at night in the control group, with no significant difference (p=0.13 and p=0.13 respectively). The percentage of total load excreted in 24 hours was lower in the experimental group (p=0.04). Conclusion: The artificial illumination of the long wavelength environment did not interfere with the activity, rest and urinary melatonin level of hospitalized postpartum women. The average time of night rest of women hospitalized in rooming-in was considered adequate.
  • Imagem de Miniatura
    Item
    Acesso aberto (Open Access)
    Estudo dos distúrbios do sono em pacientes com distonia focal: blefaroespasmo
    (Universidade Federal de São Paulo (UNIFESP), 2020-07-30) Lestingi, Silvia Cordova [UNIFESP]; Borges, Vanderci [UNIFESP]; Coelho, Fernando Morgadinho Santos [UNIFESP]; http://lattes.cnpq.br/4520146294812879; http://lattes.cnpq.br/2742450111759824; http://lattes.cnpq.br/5531342388610304; Universidade Federal de São Paulo
    Objective: We evaluated the quality of sleep and circadian rhythm in a sample of Brazilian blepharospasm patients. Methods: A total of 51 patients, who met the clinical criteria for blepharospasm, evaluated by two specialists in movement disorders, were recruited from the outpatient clinic for movement disorders of two reference centers in the city of São Paulo: Federal University of São Paulo and São Paulo Public Servants Hospital. The selected 13 patients were evaluated from 13 days before to 13 days after the use of botulinum toxin. They were interviewed, underwent physical examination and actigraphy, and completed sleep diaries. Results: Seven patients (58.8%) were at risk for developing obstructive sleep apnea syndrome (OSAS). The quality of sleep was poor for eight patients (61.5%) and showed a strong positive correlation coefficient with insomnia. After the use of botulinum toxin, the group that reported sleep improvement exhibited a 50% decrease in sleep latency. There was no change in the circadian rhythm. Patients who reported no sleep improvement after the use of botulinum toxin presented with poorer synchronization of the light-dark cycle. Conclusion: Blepharospasm patients present with poor sleep quality, displaying a strongly positive correlation with the insomnia severity index. About 50% of the patients presented with sleep improvement after using botulinum toxin. The synchronization of the light-dark cycle may influence this improvement.