Congenital Cytomegalovirus Infection as a Cause of Sensorineural Hearing Loss in a Highly Immune Population

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dc.contributor.authorYamamoto, Aparecida Y.
dc.contributor.authorMussi-Pinhata, Marisa Marcia
dc.contributor.authorIsaac, Myriam de Lima
dc.contributor.authorAmaral, Fabiana R.
dc.contributor.authorCarvalheiro, Cristina G.
dc.contributor.authorAragon, Davi C.
dc.contributor.authorSilva Manfredi, Alessandra K. da
dc.contributor.authorBoppana, Suresh B.
dc.contributor.authorBritt, William J.
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniv Alabama
dc.date.accessioned2016-01-24T14:17:32Z
dc.date.available2016-01-24T14:17:32Z
dc.date.issued2011-12-01
dc.description.abstractBackground: the burden of congenital cytomegalovirus (CMV)-associated sensorineural hearing loss (SNHL) in populations with CMV seroprevalence approaching 100% is unknown. the purpose of this study was to assess the rate, associated factors, and predictors of SNHL in CMV-infected infants identified by newborn screening in a highly seropositive maternal population.Methods: Newborns with positive saliva CMV-DNA that was confirmed by virus isolation in the first 2 weeks of life were enrolled in a prospective follow-up study to monitor hearing outcome.Results: of 12,195 infants screened, 121 (1%) were infected with CMV and 12 (10%) had symptomatic infection at birth. Hearing function could be assessed in 102/121 children who underwent at least one auditory brainstem evoked response testing at a median age of 12 months. SNHL was observed in 10/102 (9.8%; 95% confidence interval: 5.1-16.7) children. Median age at the latest hearing evaluation was 47 months (12-84 months). Profound loss (>90 dB) was found in 4/5 children with bilateral SNHL while all 5 children with unilateral loss had moderate to severe deficit. the presence of symptomatic infection at birth (odds ratio, 38.1; 95% confidence interval: 1.6-916.7) was independently associated with SNHL after adjusting for intrauterine growth restriction, gestational age, gravidity, and maternal age. Among 10 infants with SNHL, 6 (60%) were born to mothers with nonprimary CMV infection.Conclusions: Even in populations with near universal immunity to CMV, congenital CMV infection is a significant cause of SNHL demonstrating the importance of CMV as a major cause of SNHL in children worldwide. As in other populations, SNHL is more frequently observed in symptomatic CMV infection.en
dc.description.affiliationUniv São Paulo, Dept Pediat, Fac Med Ribeirao Preto, BR-14049900 São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Dept Ophtalmol Otorrinolaringol & Head & Neck Sur, Fac Med Ribeirao Preto, BR-14049900 São Paulo, Brazil
dc.description.affiliationUniv Alabama, Sch Med, Dept Pediat, Birmingham, AL USA
dc.description.affiliationUniv Alabama, Sch Med, Dept Microbiol, Birmingham, AL 35294 USA
dc.description.affiliationUniv Alabama, Sch Med, Dept Neurobiol, Birmingham, AL USA
dc.description.sourceWeb of Science
dc.description.sponsorshipNational Institutes of Health
dc.description.sponsorshipFogarty International Center
dc.description.sponsorshipNIDCD
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIDNational Institutes of Health: NIAID AI 49537
dc.description.sponsorshipIDFogarty International Center: R03 TW006480
dc.description.sponsorshipIDNIDCD: DC04162
dc.description.sponsorshipIDFAPESP: 02/04166-6
dc.format.extent1043-1046
dc.identifierhttp://dx.doi.org/10.1097/INF.0b013e31822d9640
dc.identifier.citationPediatric Infectious Disease Journal. Philadelphia: Lippincott Williams & Wilkins, v. 30, n. 12, p. 1043-1046, 2011.
dc.identifier.doi10.1097/INF.0b013e31822d9640
dc.identifier.issn0891-3668
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/34311
dc.identifier.wosWOS:000297406100009
dc.language.isoeng
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofPediatric Infectious Disease Journal
dc.rightsAcesso restrito
dc.subjectcytomegalovirusen
dc.subjectcongenital infectionen
dc.subjecthearing lossen
dc.subjectBrazilian childrenen
dc.titleCongenital Cytomegalovirus Infection as a Cause of Sensorineural Hearing Loss in a Highly Immune Populationen
dc.typeArtigo
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