beta-Carotene-loaded nanostructured lipid carriers produced by solvent displacement method

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dc.citation.volume90
dc.contributor.authorBernardes Oliveira, Davi Rocha
dc.contributor.authorMichelon, Mariano
dc.contributor.authorFurtado, Guilherme de Figueiredo
dc.contributor.authorSinigaglia-Coimbra, Rita [UNIFESP]
dc.contributor.authorCunha, Rosiane Lopes
dc.coverageAmsterdam
dc.date.accessioned2020-07-31T12:47:09Z
dc.date.available2020-07-31T12:47:09Z
dc.date.issued2016
dc.description.abstractTristearin solid lipid nanoparticles and tristearin/high oleic sunflower oil nanostructured lipid carriers were produced by solvent displacement method. All conditions allowed forming polydisperse particles within nanometric range and the presence of high oleic sunflower oil did not affect the particles mean size. Nevertheless, incorporation of beta-carotene reduced the particles polydispersity. Thermograms of solid lipid nanoparticles and nano structured lipid carriers showed that sunflower oil generated a crystal order disturbance, since nanoparticles with less-organized lipid matrix were produced. Nanostructured lipid carriers exhibited an improvement of beta-carotene loading capacity when compared with solid lipid nanoparticles, which enhanced with the increasing of high oleic sunflower oil content. Although total beta-carotene degradation was similar for all systems, color analysis showed that the degradation of encapsulated beta-carotene was lower for high sunflower oil content. Nano structured lipid carriers exhibited advantages over the solid lipid nanoparticles, such as enhanced drug loading capacity and prevention of drug expulsion, which makes this a versatile delivery system for food applications. (C) 2016 Elsevier Ltd. All rights reserved.en
dc.description.affiliationUniv Campinas UNICAMP, Fac Food Engn, Dept Food Engn, BR-13083862 Campinas, SP, Brazil
dc.description.affiliationFed Univ Sao Paulo UNIFESP, Paulista Sch Med, Ctr Electron Microscopy, BR-04023062 Sao Paulo, SP, Brazil
dc.description.affiliationUnifespCenter Electron Microscopy, Paulista School of Medicine, Universidade Federal de São Paulo (UNIFESP), 04023-062 São Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)(DEA/FEA/PROEX)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIDFAPESP: EMU2009/54137-1
dc.description.sponsorshipIDFAPESP: 2007/54520-4
dc.description.sponsorshipIDFAPESP: 2006/03263-9
dc.description.sponsorshipIDCNPq: 305477/2012-9
dc.format.extent139-146
dc.identifierhttp://dx.doi.org/10.1016/j.foodres.2016.10.038
dc.identifier.citationFood Research International. Amsterdam, v. 90, p. 139-146, 2016.
dc.identifier.doi10.1016/j.foodres.2016.10.038
dc.identifier.issn0963-9969
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/56621
dc.identifier.wosWOS:000390636700016
dc.language.isoeng
dc.publisherElsevier Science Bv
dc.relation.ispartofFood Research International
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectSolid lipid nanoparticleen
dc.subjectNanostructured lipid carrieren
dc.subjectbeta-caroteneen
dc.subjectHigh oleic sunflower oilen
dc.subjectSolvent displacementen
dc.titlebeta-Carotene-loaded nanostructured lipid carriers produced by solvent displacement methoden
dc.typeinfo:eu-repo/semantics/article
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