Effects of acute creatine supplementation on iron homeostasis and uric acid-based antioxidant capacity of plasma after wingate test

Página do item simplificado
dc.contributor.authorBarros, Marcelo P.
dc.contributor.authorGanini, Douglas
dc.contributor.authorLorenco-Lima, Leandro
dc.contributor.authorSoares, Chrislaine O.
dc.contributor.authorPereira, Benedito
dc.contributor.authorBechara, Etelvino J. H. [UNIFESP]
dc.contributor.authorSilveira, Leonardo R.
dc.contributor.authorCuri, Rui
dc.contributor.authorSouza-Junior, Tacito P.
dc.contributor.institutionUniv Fed Parana
dc.contributor.institutionUniv Cruzeiro Sul
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:27:22Z
dc.date.available2016-01-24T14:27:22Z
dc.date.issued2012-06-12
dc.description.abstractBackground: Dietary creatine has been largely used as an ergogenic aid to improve strength and athletic performance, especially in short-term and high energy-demanding anaerobic exercise. Recent findings have also suggested a possible antioxidant role for creatine in muscle tissues during exercise. Here we evaluate the effects of a 1-week regimen of 20 g/day creatine supplementation on the plasma antioxidant capacity, free and heme iron content, and uric acid and lipid peroxidation levels of young subjects (23.1 +/- 5.8 years old) immediately before and 5 and 60 min after the exhaustive Wingate test.Results: Maximum anaerobic power was improved by acute creatine supplementation (10.5 %), but it was accompanied by a 2.4-fold increase in pro-oxidant free iron ions in the plasma. However, potential iron-driven oxidative insult was adequately counterbalanced by proportional increases in antioxidant ferric-reducing activity in plasma (FRAP), leading to unaltered lipid peroxidation levels. Interestingly, the FRAP index, found to be highly dependent on uric acid levels in the placebo group, also had an additional contribution from other circulating metabolites in creatine-fed subjects.Conclusions: Our data suggest that acute creatine supplementation improved the anaerobic performance of athletes and limited short-term oxidative insults, since creatine-induced iron overload was efficiently circumvented by acquired FRAP capacity attributed to: overproduction of uric acid in energy-depleted muscles (as an end-product of purine metabolism and a powerful iron chelating agent) and inherent antioxidant activity of creatine.en
dc.description.affiliationUniv Fed Parana, Dept Phys Educ, BR-80215370 Curitiba, Parana, Brazil
dc.description.affiliationUniv Cruzeiro Sul, Inst Phys Activ & Sports Sci ICAFE, Postgrad Program Human Movement Sci, BR-01506000 São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Dept Biochem, BR-05508900 São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Sch Phys Educ & Sports, BR-05508900 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, UNIFESP, BR-09972270 Diadema, Brazil
dc.description.affiliationUniv São Paulo USP RP, Sch Phys Educ & Sports, BR-05508900 Ribeirao Preto, Brazil
dc.description.affiliationUniv São Paulo, Dept Physiol & Biophys, BR-05508900 São Paulo, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, UNIFESP, BR-09972270 Diadema, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipInternational Foundation for Science
dc.description.sponsorshipIDFAPESP: FAPESP 02/09405-9
dc.description.sponsorshipIDCNPq: CNPq 312404/2009-3
dc.description.sponsorshipIDInternational Foundation for Science: F/3816-1
dc.format.extent10
dc.identifierhttp://dx.doi.org/10.1186/1550-2783-9-25
dc.identifier.citationJournal of the International Society of Sports Nutrition. London: Biomed Central Ltd, v. 9, 10 p., 2012.
dc.identifier.doi10.1186/1550-2783-9-25
dc.identifier.fileWOS000309286100001.pdf
dc.identifier.issn1550-2783
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/34993
dc.identifier.wosWOS:000309286100001
dc.language.isoeng
dc.publisherBiomed Central Ltd
dc.relation.ispartofJournal of the International Society of Sports Nutrition
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCreatineen
dc.subjectIron homeostasisen
dc.subjectAntioxidanten
dc.subjectPlasmaen
dc.subjectWingateen
dc.subjectAnaerobic exerciseen
dc.subjectOxidative stressen
dc.subjectUric aciden
dc.titleEffects of acute creatine supplementation on iron homeostasis and uric acid-based antioxidant capacity of plasma after wingate testen
dc.typeinfo:eu-repo/semantics/article
Arquivos
Pacote Original
Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
WOS000309286100001.pdf
Tamanho:
647.83 KB
Formato:
Adobe Portable Document Format
Descrição:
Baixar
Coleções
ICAQF - Artigos