Obsessive-compulsive symptoms are associated with psychiatric comorbidities, behavioral and clinical problems: a population-based study of Brazilian school children

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dc.citation.issue2
dc.citation.volume25
dc.contributor.authorAlvarenga, Pedro G.
dc.contributor.authorRosario, Maria C. do [UNIFESP]
dc.contributor.authorCesar, Raony C.
dc.contributor.authorManfro, Gisele G.
dc.contributor.authorMoriyama, Tais S.
dc.contributor.authorBloch, Michael H.
dc.contributor.authorShavitt, Roseli G.
dc.contributor.authorHoexter, Marcelo Q.
dc.contributor.authorCoughlin, Catherine G.
dc.contributor.authorLeckman, James F.
dc.contributor.authorMiguel, Euripedes C.
dc.coverageNew York
dc.date.accessioned2020-11-03T14:40:34Z
dc.date.available2020-11-03T14:40:34Z
dc.date.issued2016
dc.description.abstractPediatric-onset obsessive-compulsive disorder (OCD) is underdiagnosed, and many affected children are untreated. The present study seeks to evaluate the presence and the clinical impact of OCD and obsessive-compulsive symptoms (OCS) in a large sample of school-age children. In Phase I, we performed an initial screening using the Family History Screen (FHS). In Phase II, we identified an "at-risk" sample, as well as a randomly selected group of children. A total of 2,512 children (6-12 years old) were assessed using the FHS, the Development and Well-Being Assessment (DAWBA), the Strengths and Difficulties Questionnaire (SDQ), and the Child Behavior Checklist (CBCL). Data analyses included descriptive and multivariate analytical techniques. 2,512 children (mean age: 8.86 +/- A 1.84 years; 55.0 % male) were categorized into one of the three diagnostic groups: OCD (n = 77), OCS (n = 488), and unaffected controls (n = 1,947). There were no significant socio-demographic differences (age, gender, socioeconomic status) across groups. The OCS group resembled the OCD on overall impairment, including school problems and delinquent behaviors. However, the OCD group did have significantly higher rates of several comorbid psychiatric disorders, including separation anxiety, generalized anxiety, and major depressive disorder, than OCS or unaffected controls. Moreover, the OCD group also scored higher than the SDQ, as well as on each of CBCL items rated by the parent. Our findings suggest that there is a psychopathological continuum between OCS and OCD in school-aged children. The presence of OCS is associated with functional impairment, which needs further investigation in longitudinal studies.en
dc.description.affiliationUniv Sao Paulo, Sch Med, Dept & Inst Psychiat, Rua Dr Ovidio Pires de Campos 785, BR-01060970 Sao Paulo, SP, Brazil
dc.description.affiliationCNPq, Natl Inst Dev Psychiat Children & Adolescents, Rua Dr Ovidio Pires de Campos, BR-01060970 Sao Paulo, SP, Brazil
dc.description.affiliationFed Univ Sao Paulo UNIFESP, Dept Psychiat, Child & Adolescent Psychiat Unit UPIA, Rua Pedro de Toledo 590, BR-04038020 Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Rio Grande do Sul, Hosp Clin Porto Alegre, Rua Ramiro Barcelos 2350, BR-90035903 Porto Alegre, RS, Brazil
dc.description.affiliationYale Univ, Sch Med, Ctr Child Study, 230 South Frontage Rd, New Haven, CT 06519 USA
dc.description.affiliationUnifespFed Univ Sao Paulo UNIFESP, Dept Psychiat, Child & Adolescent Psychiat Unit UPIA, Rua Pedro de Toledo 590, BR-04038020 Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipNational Institutes of Health
dc.description.sponsorshipTourette Syndrome Association
dc.description.sponsorshipPatterson Trust Foundation
dc.description.sponsorshipRembrandt Foundation
dc.description.sponsorshipGrifols, LLC
dc.description.sponsorshipKlingenstein Third Generation Foundation
dc.description.sponsorshipOxford University Press
dc.format.extent175-182
dc.identifierhttps://doi.org/10.1007/s00787-015-0723-3
dc.identifier.citationEuropean Child & Adolescent Psychiatry. New York, v. 25, n. 2, p. 175-182, 2016.
dc.identifier.doi10.1007/s00787-015-0723-3
dc.identifier.issn1018-8827
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/58623
dc.identifier.wosWOS:000369325900006
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofEuropean Child & Adolescent Psychiatry
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectChild and adolescent psychiatryen
dc.subjectComorbiditiesen
dc.subjectEpidemiologyen
dc.subjectObsessive-compulsive disorderen
dc.subjectSchool-aged childrenen
dc.titleObsessive-compulsive symptoms are associated with psychiatric comorbidities, behavioral and clinical problems: a population-based study of Brazilian school childrenen
dc.typeinfo:eu-repo/semantics/article
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