Feeding induced by increasing doses of neuropeptide Y: Dual effect on hypothalamic serotonin release in normal rats

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dc.contributor.authorMori, Rosana Cristina Tieko [UNIFESP]
dc.contributor.authorTelles, Monica Marques [UNIFESP]
dc.contributor.authorGuimaraes, Regina Barros [UNIFESP]
dc.contributor.authorNovo, Neil Ferreira [UNIFESP]
dc.contributor.authorJuliano, Yara [UNIFESP]
dc.contributor.authorNascimento, Claudia Maria da Penha Oller do [UNIFESP]
dc.contributor.authorRibeiro, Eliane Beraldi [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T12:37:18Z
dc.date.available2016-01-24T12:37:18Z
dc.date.issued2004-08-01
dc.description.abstractEndogenous neuropeptide Y (NPY) levels increase during fasting and before dark onset in rats. the feeding that follows these states elicits the release of serotonin in the lateral hypothalamus (LH), as part of the physiological mechanisms controlling satiety. With the hypothesis that exogenous NPY-induced feeding should also stimulate serotonin, we measured its release in the LH of non-fasted rats, which received a single intracerebroventricular injection of either 1.0, 2.0, or 5.0 mug of NPY. After 1.0 mug, the cumulative 2-h intake was of 13 g and serotonin release significantly increased (54% peak). These feeding and serotonergic responses were highly similar to the ones we observed in a previous study, in which feeding followed an overnight fast. Thus, the 1.0 mug NPY dose stimulated intake while preserving the normal serotonergic activation. Contrarily, as the NPY dose was increased to either 2.0 or 5.0 mug, the cumulative 2-h intakes were of 18 g, but the serotonergic stimulation was absent. It is suggested that this dual NPY effect relies on a finely tuned control mechanism, reflecting the existence of a narrow range of NPY levels within which the serotonergic stimulation resembles those seen in physiological states.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Fisiol, Div Neurophysiol & Endocrine Physiol, BR-04023062 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Med, Div Prevent Med, BR-04023062 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Fisiol, Div Neurophysiol & Endocrine Physiol, BR-04023062 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Med, Div Prevent Med, BR-04023062 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent235-239
dc.identifierhttps://dx.doi.org/10.1080/10284150400012794
dc.identifier.citationNutritional Neuroscience. Abingdon: Taylor & Francis Ltd, v. 7, n. 4, p. 235-239, 2004.
dc.identifier.doi10.1080/10284150400012794
dc.identifier.issn1028-415X
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/27862
dc.identifier.wosWOS:000226385100006
dc.language.isoeng
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofNutritional Neuroscience
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://journalauthors.tandf.co.uk/permissions/reusingOwnWork.asp
dc.subjectBrain microdialysisen
dc.subjectFood intakeen
dc.subjectNeuropeptideen
dc.subjectYen
dc.subjectLateral hypothalamusen
dc.subjectSerotoninen
dc.titleFeeding induced by increasing doses of neuropeptide Y: Dual effect on hypothalamic serotonin release in normal ratsen
dc.typeinfo:eu-repo/semantics/article
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