Fatty-acid-mediated hypothalamic inflammation and epigenetic programming

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dc.citation.volume42
dc.contributor.authorCesar, Helena C. [UNIFESP]
dc.contributor.authorPisani, Luciana Pellegrini [UNIFESP]
dc.coverageNew York
dc.date.accessioned2020-07-17T14:02:37Z
dc.date.available2020-07-17T14:02:37Z
dc.date.issued2017
dc.description.abstractA high-fat diet is the main environmental cue that has been studied in the hypothalamus since the discovery of its connection with hypothalamic inflammation. Current evidence shows hypothalamic inflammation as a likely mechanism for the dysregulation on the homeostatic control of energy balance, which leads to metabolic alterations and obesity. Although this mechanism seems to be reversible when set during adulthood, we argue whether dietary fatty acids, during critical periods of development, could affect hypothalamic function permanently and set an increased susceptibility to obesity. We found few experimental studies that looked at programming induced by different fatty acids on the hypothalamus. They clearly showed a connection between maternal fat diet, hypothalamic inflammation and metabolic alterations in the offspring. We found that not only a high-fat diet but also a normolipidic diet with unbalanced quantities of different fatty acids produced diverse inflammatory responses on the hypothalamus. Therefore, strategies of manipulating dietary fatty acids in pregnant and lactating women may have great impact on the population's future health. However, more research is still needed on the effects of fatty acids and the hypothalamic inflammation on programming. (C) 2016 Elsevier Inc. All rights reserved.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Biociencias, Santos, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Biociencias, Santos, SP, Brazil
dc.description.sourceWeb of Science
dc.format.extent1-6
dc.identifierhttp://dx.doi.org/10.1016/j.jnutbio.2016.08.008
dc.identifier.citationJournal Of Nutritional Biochemistry. New York, v. 42, p. 1-6, 2017.
dc.identifier.doi10.1016/j.jnutbio.2016.08.008
dc.identifier.issn0955-2863
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/54905
dc.identifier.wosWOS:000398010600001
dc.language.isoeng
dc.publisherElsevier Science Inc
dc.relation.ispartofJournal Of Nutritional Biochemistry
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectInflammationen
dc.subjectProgrammingen
dc.subjectFatty acidsen
dc.subjectObesityen
dc.subjectHypothalamusen
dc.subjectAppetite regulationen
dc.titleFatty-acid-mediated hypothalamic inflammation and epigenetic programmingen
dc.typeinfo:eu-repo/semantics/article
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