Estudo multicêntrico brasileiro de 71 pacientes com arterite de Takayasu juvenil: características clínicas e angiográficas

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dc.citation.issue2
dc.citation.volume56
dc.contributor.authorClemente, Gleice [UNIFES]
dc.contributor.authorHilario, Maria Odete [UNIFESP]
dc.contributor.authorLen, Claudio [UNIFESP]
dc.contributor.authorSilva, Clovis A.
dc.contributor.authorSallum, Adriana M.
dc.contributor.authorCampos, Lucia M.
dc.contributor.authorSacchetti, Silvana
dc.contributor.authordos Santos, Maria Carolina
dc.contributor.authorAlves, Andressa Guariento
dc.contributor.authorFerriani, Virginia P.
dc.contributor.authorSztajnbok, Flavio
dc.contributor.authorGasparello, Rozana
dc.contributor.authorOliveira, Sheila Knupp
dc.contributor.authorLessa, Marise
dc.contributor.authorBica, Blanca
dc.contributor.authorCavalcanti, Andre
dc.contributor.authorRobazzi, Teresa
dc.contributor.authorBandeira, Marcia
dc.contributor.authorTerreri, Maria Teresa [UNIFESP]
dc.coverageNew York
dc.date.accessioned2020-08-21T16:59:58Z
dc.date.available2020-08-21T16:59:58Z
dc.date.issued2016
dc.description.abstractObjective: To describe the clinical and angiographic characteristics of Takayasu's arteritis in Brazilian children and adolescents. Methods: A retrospective data collection was performed in 71 children and adolescents followed in 10 Brazilian reference centers in Pediatric Rheumatology. The evaluation was carried out in three different time points: from onset of symptoms to diagnosis, from the 6th to 12th month of diagnosis, and in the last visit. Results: Of 71 selected patients, 51 (71.8%) were girls. The mean age of onset of symptoms and of time to diagnosis was 9.2 (+/- 4.2) years and 1.2 (+/- 1.4) years, respectively. At the end of the study, 20 patients were in a state of disease activity, 39 in remission and 5 had evolved to death. The most common symptoms in baseline assessment, second evaluation, and final evaluation were, respectively: constitutional, musculoskeletal, and neurological symptoms. A decrease in peripheral pulses was the most frequent cardiovascular signal, and an increase in erythrocyte sedimentation rate was the most frequent laboratory finding in all three evaluation periods. The tuberculin test was positive in 41% of those tested. Stenosis was the most frequent angiographic lesion, abdominal artery was the most affected segment, and angiographic type IV the most frequent. Most (90%) participants were treated with glucocorticoids, 85.9% required another immunosuppressive drug, and 29.6% underwent angioplasty. Conclusion: This is the largest study on juvenile-onset Takayasu arteritis, and a high number of patients under the age of 10 years, with predominance of constitutional symptoms early in the disease, was observed. (C) 2016 Elsevier Editora Ltda. All rights reserved.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Pediat, Sect Pediat Rheumatol, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Sao Paulo, Inst Crianca, Pediat Rheumatol Sect, Sao Paulo, SP, Brazil
dc.description.affiliationSanta Casa Misericordia Sao Paulo, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Sao Paulo, Sch Med, Ribeirao Preto, SP, Brazil
dc.description.affiliationUniv Estado Rio de Janeiro, BR-20550011 Rio De Janeiro, RJ, Brazil
dc.description.affiliationUniv Fed Rio de Janeiro, Inst Pediat Martagao Gesteira, Rio De Janeiro, RJ, Brazil
dc.description.affiliationUniv Fed Rio de Janeiro, Rheumatol Unit, Rio De Janeiro, RJ, Brazil
dc.description.affiliationUniv Fed Pernambuco, Rheumatol Unit, Recife, PE, Brazil
dc.description.affiliationUniv Fed Bahia, Salvador, BA, Brazil
dc.description.affiliationHosp Pequeno Principe, Curitiba, Parana, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Pediat, Sect Pediat Rheumatol, Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.format.extent145-151
dc.identifierhttp://dx.doi.org/10.1016/j.rbre.2016.01.004
dc.identifier.citationRevista Brasileira De Reumatologia. New York, v. 56, n. 2, p. 145-151, 2016.
dc.identifier.doi10.1016/j.rbre.2016.01.004
dc.identifier.fileS0482-50042016000200145-en.pdf
dc.identifier.fileS0482-50042016000200145-pt.pdf
dc.identifier.issn0482-5004
dc.identifier.scieloS0482-50042016000200145
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/57815
dc.identifier.wosWOS:000378176000010
dc.language.isoeng
dc.publisherElsevier Science Inc
dc.relation.ispartofRevista Brasileira De Reumatologia
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTakayasu's arteritisen
dc.subjectChilden
dc.subjectTeenageren
dc.subjectImageen
dc.subjectArterite de Takayasupt
dc.subjectCrianc¸a Adolescentept
dc.subjectImagempt
dc.titleEstudo multicêntrico brasileiro de 71 pacientes com arterite de Takayasu juvenil: características clínicas e angiográficaspt
dc.title.alternativeBrazilian multicenter study of 71 patients with juvenile-onset Takayasu's arteritis: clinical and angiographic featuresen
dc.typeinfo:eu-repo/semantics/article
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