Isolation and characterisation of genomic and cDNA clones coding for a serine-, alanine-, and proline-rich protein of Trypanosoma cruzi

Página do item simplificado
dc.contributor.authorCarmo, Mirian Silva do [UNIFESP]
dc.contributor.authorSantos, Marcia Regina Machado dos [UNIFESP]
dc.contributor.authorCummings, Leda Maria [UNIFESP]
dc.contributor.authorAraya, Jorge Enrique
dc.contributor.authorYamauchi, Lucy Megumi [UNIFESP]
dc.contributor.authorYoshida, Nobuko [UNIFESP]
dc.contributor.authorMortara, Renato Arruda [UNIFESP]
dc.contributor.authorSilveira, José Franco da [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Antofagasta
dc.date.accessioned2016-01-24T12:31:19Z
dc.date.available2016-01-24T12:31:19Z
dc.date.issued2001-03-01
dc.description.abstractWe report here the isolation and characterisation of genomic and cDNA clones encoding a Serine-, Alanine-, and Proline-rich protein (SAP) of Trypanosoma cruzi metacyclic trypomastigotes. the deduced peptides translated from these clones were characterised by a high content of residues of alanine, proline, serine, glycine, valine, and threonine distributed in several repeats: P2-4, S2-3, A(2-3), AS, SA, PA, AP, SP, PS, and TP. the repeats are partially homologous to the serine-, alanine-, and proline-containing motifs of Leishmania major and Leishmania mexicana proteophosphoglycans. Genes coding for SAP are part of a polymorphic family whose members are linked to members of gp85/ sialidase and mucin-like gene families. This is consistent with the hypothesis that this genetic organisation could be a means by which T. cruzi co-ordinates the expression of major surface proteins. (C) 2001 Australian Society for Parasitology Inc. Published by Elsevier B.V. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med, Dept Microbiol Imunol & Parasitol, BR-04023062 São Paulo, Brazil
dc.description.affiliationUniv Antofagasta, Unidad Parasitol, Antofagasta, Chile
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med, Dept Microbiol Imunol & Parasitol, BR-04023062 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent259-264
dc.identifierhttps://dx.doi.org/10.1016/S0020-7519(00)00170-3
dc.identifier.citationInternational Journal for Parasitology. Oxford: Pergamon-Elsevier B.V., v. 31, n. 3, p. 259-264, 2001.
dc.identifier.doi10.1016/S0020-7519(00)00170-3
dc.identifier.issn0020-7519
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/26500
dc.identifier.wosWOS:000167627700004
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofInternational Journal for Parasitology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectTrypanosoma cruzien
dc.subjectMetacyclic trypomastigoteen
dc.subjectSerine-, alanine-, and proline-rich protein (SAP)en
dc.subjectSurface membrane proteinen
dc.subjectMultigene familyen
dc.titleIsolation and characterisation of genomic and cDNA clones coding for a serine-, alanine-, and proline-rich protein of Trypanosoma cruzien
dc.typeinfo:eu-repo/semantics/article
Arquivos
Coleções
EPM - Artigos