Pancreatitis Subtypes Survey in 852 Childhood-Onset Systemic Lupus Erythematosus Patients

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dc.citation.issue2
dc.citation.volume62
dc.contributor.authorMarques, Victor L. S.
dc.contributor.authorGormezano, Natali W. S.
dc.contributor.authorBonfa, Eloisa
dc.contributor.authorAikawa, Nadia E.
dc.contributor.authorTerreri, Maria T. [UNIFESP]
dc.contributor.authorPereira, Rosa M.
dc.contributor.authorMagalhaes, Claudia S.
dc.contributor.authorGuariento, Andressa
dc.contributor.authorAppenzeller, Simone
dc.contributor.authorFerriani, Virginia P.
dc.contributor.authorBarbosa, Cassia M.
dc.contributor.authorRamos, Valeria C.
dc.contributor.authorLotufo, Simone
dc.contributor.authorSilva, Clovis A.
dc.coveragePhiladelphia
dc.date.accessioned2020-11-03T14:40:35Z
dc.date.available2020-11-03T14:40:35Z
dc.date.issued2016
dc.description.abstractObjective:Pancreatitis is a rare and a life-threatening systemic lupus erythematosus (SLE) manifestation in childhood-onset SLE (cSLE). The objective of this study was to systematically classify pancreatitis in cSLE according to the International Study Group of Pediatric Pancreatitis and determine the overall prevalence, clinical features, laboratory, and first episode outcomes.Methods:A multicenter cohort study in 10 pediatric rheumatology centers, including 852 patients with cSLE.Results:Pancreatitis was diagnosed in 22 of 852 (2.6%) patients with cSLE. It was classified as acute pancreatitis in 20 (91%), acute recurrent pancreatitis in 2 (9%), and none of them had chronic pancreatitis. None of them had gallstones, traumatic pancreatitis, or reported alcohol/tobacco use. The comparison of patients with pancreatitis (first episode) and without this complication revealed a shorter disease duration (1 [0-10] vs 4 [0-23] years, P<0.0001) and higher median of Systemic Lupus Erythematosus Disease Activity Index 2000 (21 [0-41] vs 2 [0-45], P<0.0001). The frequencies of fever (P<0.0001), weight loss (P<0.0001), serositis (P<0.0001), nephritis (P<0.0001), arterial hypertension (P<0.0001), acute renal failure (P<0.0001), macrophage activation syndrome (P<0.0001), and death (P=0.001) were also higher in patients with pancreatitis. The frequencies of intravenous methylprednisolone use (P<0.0001) and the median of prednisone dose (55 [15-60] vs 11 [1-90] mg/day, P<0.0001) were significantly higher in patients with pancreatitis. Of note, the 2 patients with acute recurrent pancreatitis had 2 episodes, with pain-free interval of 1 and 4 years.Conclusions:This was the first study characterizing pancreatitis using the International Study Group of Pediatric Pancreatitis standardized definitions in patients with cSLE showing that the predominant form is acute pancreatitis seen in association with glucocorticoid treatment and active severe disease.en
dc.description.affiliationUniv Sao Paulo, Fac Med, Pediat Rheumatol Unit, BR-05403000 Sao Paulo, SP, Brazil
dc.description.affiliationUniv Sao Paulo, Fac Med, Div Rheumatol, BR-05403000 Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Pediat Rheumatol Unit, Sao Paulo, Brazil
dc.description.affiliationSao Paulo State Univ, UNESP, Fac Med Botucatu, Sao Paulo, Brazil
dc.description.affiliationIrmandade Santa Casa de Misericordia Sao Paulo, Sao Paulo, Brazil
dc.description.affiliationUniv Estadual Campinas, Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, Ribeirao Preto Med Sch, BR-05403000 Sao Paulo, SP, Brazil
dc.description.affiliationHosp Infantil Darcy Vargas, Sao Paulo, Brazil
dc.description.affiliationPontifical Catholic Univ Sorocaba, Sao Paulo, Brazil
dc.description.affiliationHosp Municipal Infantil Menino Jesus, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Pediat Rheumatol Unit, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico
dc.description.sponsorshipFederico Foundation
dc.description.sponsorshipNucleo de Apoio a Pesquisa "Saude da Crianca e do Adolescente" da USP (NAP-CriAd)
dc.description.sponsorshipIDCNPq: 2009/51897-5
dc.description.sponsorshipIDCNPq: 301805/2013-0
dc.description.sponsorshipIDCNPq: 302724/2011-7
dc.format.extent328-334
dc.identifierhttps://doi.org/10.1097/MPG.0000000000000990
dc.identifier.citationJournal Of Pediatric Gastroenterology And Nutrition. Philadelphia, v. 62, n. 2, p. 328-334, 2016.
dc.identifier.doi10.1097/MPG.0000000000000990
dc.identifier.issn0277-2116
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/58629
dc.identifier.wosWOS:000369292300011
dc.language.isoeng
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofJournal Of Pediatric Gastroenterology And Nutrition
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectchildhood-onset systemic lupus erythematosusen
dc.subjectglucocorticoiden
dc.subjectpancreatitisen
dc.subjectSystemic Lupus Erythematosus Disease Activity Indexen
dc.titlePancreatitis Subtypes Survey in 852 Childhood-Onset Systemic Lupus Erythematosus Patientsen
dc.typeinfo:eu-repo/semantics/article
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