Shortcuts to a functional adipose tissue: The role of small non-coding RNAs

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dc.citation.volume12]
dc.contributor.authorBrandao, Bruna B. [UNIFESP]
dc.contributor.authorGuerra, Beatriz A.[UNIFESP]
dc.contributor.authorMori, Marcelo A. [UNIFESP]
dc.coverageAmsterdam
dc.date.accessioned2020-06-26T16:30:13Z
dc.date.available2020-06-26T16:30:13Z
dc.date.issued2017
dc.description.abstractMetabolic diseases such as type 2 diabetes are a major public health issue worldwide. These diseases are often linked to a dysfunctional adipose tissue. Fat is a large, heterogenic, pleiotropic and rather complex tissue. It is found in virtually all cavities of the human body, shows unique plasticity among tissues, and harbors many cell types in addition to its main functional unit - the adipocyte. Adipose tissue function varies depending on the localization of the fat depot, the cell composition of the tissue and the energy status of the organism. While the white adipose tissue (WAT) serves as the main site for triglyceride storage and acts as an important endocrine organ, the brown adipose tissue (BAT) is responsible for thermogenesis. Beige adipocytes can also appear in WAT depots to sustain heat production upon certain conditions, and it is becoming clear that adipose tissue depots can switch phenotypes depending on cell autonomous and non-autonomous stimuli. To maintain such degree of plasticity and respond adequately to changes in the energy balance, three basic processes need to be properly functioning in the adipose tissue: i) adipogenesis and adipocyte turnover, ii) metabolism, and iii) signaling. Here we review the fundamental role of small non-coding RNAs (sncRNAs) in these processes, with focus on microRNAs, and demonstrate their importance in adipose tissue function and whole body metabolic control in mammals.en
dc.description.affiliationUniv Fed Sao Paulo, Program Mol Biol, Sao Paulo, Brazil
dc.description.affiliationUniv Estadual Campinas, Dept Biochem & Tissue Biol, Campinas, SP, Brazil
dc.description.affiliationUniv Estadual Campinas, Program Genet & Mol Biol, Campinas, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Program Mol Biol, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
dc.description.sponsorshipFundo de Apoio ao Ensino, a Pesquisa e Extensao (FAEPEX/UNICAMP)
dc.description.sponsorshipIDFAPESP: 2015/01316-7
dc.description.sponsorshipIDFAPESP: 2015/03292-8
dc.description.sponsorshipIDCNPq: 444424/2014-8
dc.description.sponsorshipIDFAEPEX/UNICAMP: 2408/16
dc.format.extent82-102
dc.identifierhttp://dx.doi.org/10.1016/j.redox.2017.01.020]
dc.identifier.citationRedox Biology. Amsterdam, v. 12, p. 82-102, 2017.
dc.identifier.doi10.1016/j.redox.2017.01.020
dc.identifier.fileWOS000403328700008.pdf
dc.identifier.issn2213-2317
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/53429
dc.identifier.wosWOS:000403328700008
dc.language.isoeng
dc.publisherElsevier Science Bv
dc.relation.ispartofRedox Biology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAdipose tissueen
dc.subjectMicroRNAsen
dc.subjectSmall non-coding RNAsen
dc.subjectObesityen
dc.subjectDiabetesen
dc.titleShortcuts to a functional adipose tissue: The role of small non-coding RNAsen
dc.typeinfo:eu-repo/semantics/article
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