Cardiovascular mechanisms activated by microinjection of baclofen into NTS of conscious rats

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dc.contributor.authorLandulpho, Carlos Daniel Almeida Pitanga
dc.contributor.authorDias, Ana Carolina Rodrigues
dc.contributor.authorColombari, Eduardo [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T12:33:44Z
dc.date.available2016-01-24T12:33:44Z
dc.date.issued2003-03-01
dc.description.abstractThe peripheral mechanisms responsible for pressor response produced by microinjections of baclofen (GABA(B) agonist) into the nucleus tractus solitarii (NTS) of conscious rats were studied. Bilateral microinjections of baclofen (10-1,000 pmol/100 nl) produced a dose-related increase in mean arterial pressure (MAP) and heart rate. the maximal response was observed after 15 min. Intravenous injection of prazosin decreased MAP to control levels. Subsequent treatment with Manning compound (vasopressin receptor antagonist; iv) produced an additional decrease in MAP. in a different group of rats, vasopressin antagonist was injected first and MAP was significantly decreased; however, it remained elevated compared with prebaclofen injection levels. Subsequent treatment with prazosin abolished the baclofen-induced pressor response. Reductions in baclofen-induced pressor response with prazosin treatment were followed by a reflex tachycardia in animals that received a 100 pmol/100 nl dose of baclofen. the tachycardia was not observed with a dose of 1,000 pmol/100 nl. the pressor response induced by microinjection of baclofen into the NTS of conscious rats may be produced by both increases in sympathetic tonus and vasopressin release.en
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med, Dept Physiol, BR-04023060 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med, Dept Physiol, BR-04023060 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extentH987-H993
dc.identifierhttp://dx.doi.org/10.1152/ajpheart.00447.2002
dc.identifier.citationAmerican Journal of Physiology-heart and Circulatory Physiology. Bethesda: Amer Physiological Soc, v. 284, n. 3, p. H987-H993, 2003.
dc.identifier.doi10.1152/ajpheart.00447.2002
dc.identifier.issn0363-6135
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/27158
dc.identifier.wosWOS:000180885200029
dc.language.isoeng
dc.publisherAmer Physiological Soc
dc.relation.ispartofAmerican Journal of Physiology-heart and Circulatory Physiology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectGABA(B) agonisten
dc.subjectprazosinen
dc.subjectblood pressureen
dc.subjectvasopressinen
dc.subjectcardiovascular controlen
dc.subjectbaroreflexen
dc.titleCardiovascular mechanisms activated by microinjection of baclofen into NTS of conscious ratsen
dc.typeinfo:eu-repo/semantics/article
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