Modafinil Prevents Inhibitory Avoidance Memory Deficit Induced by Sleep Deprivation in Rats

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dc.contributor.authorMoreira, Karin Monteiro [UNIFESP]
dc.contributor.authorFerreira, Tatiana Lima [UNIFESP]
dc.contributor.authorHipólide, Débora Cristina [UNIFESP]
dc.contributor.authorFomari, Raquel Vecchio [UNIFESP]
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.authorMenezes Oliveira, Maria Gabriela [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade Federal do ABC (UFABC)
dc.contributor.institutionUniv Groningen, Univ Med Ctr Groningen
dc.date.accessioned2018-06-18T12:11:59Z
dc.date.available2018-06-18T12:11:59Z
dc.date.issued2010-07-01
dc.description.abstractStudy Objectives: Evaluation of modafinil effects on the inhibitory avoidance task (IA).Design: Rats were trained on a multiple trial IA task after receiving modafinil or vehicle injections. In experiment 1 they were trained with a weak protocol under baseline condition and in experiment 2, with a stronger protocol under sleep-deprivation condition.Results: In experiment 1 modafinil improved rats' acquisition whereas the retention test remained unaffected. In Experiment 2 modafinil did not interfere with training performance, but the lower dose prevented the retention impairment in sleep-deprived animals.Conclusions: Modafinil is able to improve acquisition in normal rats and reverse the long-term memory impairment induced by sleep-deprivation.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Psychobiol, BR-04024002 Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Biol Sci, BR-04024002 Sao Paulo, Brazil
dc.description.affiliationUniv Fed ABC, Math Computat & Cognit Ctr, Santo Andre, SP, Brazil
dc.description.affiliationUniv Groningen, Univ Med Ctr Groningen, Dept Neurosci, NL-9713 AV Groningen, Netherlands
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Psychobiol, BR-04024002 Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Biol Sci, BR-04024002 Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent990-993
dc.identifierhttps://doi.org/10.1093/sleep/33.7.99
dc.identifier.citationSleep. Westchester: Amer Acad Sleep Medicine, v. 33, n. 7, p. 990-993, 2010.
dc.identifier.issn0161-8105
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/45609
dc.identifier.wosWOS:000279365600020
dc.language.isoeng
dc.publisherAmer Acad Sleep Medicine
dc.relation.ispartofSleep
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCognitive enhanceren
dc.subjectemotional memoryen
dc.subjectacquisitionen
dc.subjectretrievalen
dc.subjectlearningen
dc.subjectsleepen
dc.titleModafinil Prevents Inhibitory Avoidance Memory Deficit Induced by Sleep Deprivation in Ratsen
dc.typeinfo:eu-repo/semantics/article
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