Fungicidal activity of peptides encoded by immunoglobulin genes

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dc.citation.volume7
dc.contributor.authorPolonelli, Luciano
dc.contributor.authorCiociola, Tecla
dc.contributor.authorSperinde, Martina
dc.contributor.authorGiovati, Laura
dc.contributor.authorD'Adda, Tiziana
dc.contributor.authorGalati, Serena
dc.contributor.authorTravassos, Luiz R. [UNIFESP]
dc.contributor.authorMagliani, Walter
dc.contributor.authorConti, Stefania
dc.coverageLondon
dc.date.accessioned2020-08-04T13:40:12Z
dc.date.available2020-08-04T13:40:12Z
dc.date.issued2017
dc.description.abstractEvidence from previous works disclosed the antimicrobial, antiviral, anti-tumour and/or immunomodulatory activity exerted, through different mechanisms of action, by peptides expressed in the complementarity-determining regions or even in the constant region of antibodies, independently from their specificity and isotype. Presently, we report the selection, from available databases, of peptide sequences encoded by immunoglobulin genes for the evaluation of their potential biological activities. Synthetic peptides representing the translated products of J lambda and J heavy genes proved to act in vitro against pathogenic fungi, entering yeast cells and causing their death, and exerted a therapeutic effect in a Galleria mellonella model of infection by Candida albicans. No haemolytic, cytotoxic and genotoxic effects were observed on mammalian cells. These findings raise the hypothesis that antibodies could be the evolutionary result of the adaptive combination of gene products ancestrally devoted to innate antimicrobial immunity.en
dc.description.affiliationUniv Parma, Dept Med & Surg, Parma, Italy
dc.description.affiliationUniv Parma, Dept Chem Life Sci & Environm Sustainabil, Parma, Italy
dc.description.affiliationFed Univ Sao Paulo UNIFESP, Expt Oncol Unit, Sao Paulo, Brazil
dc.description.affiliationUnifespFed Univ Sao Paulo UNIFESP, Expt Oncol Unit, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent-
dc.identifierhttp://dx.doi.org/10.1038/s41598-017-11396-6
dc.identifier.citationScientific Reports. London, v. 7, p. -, 2017.
dc.identifier.doi10.1038/s41598-017-11396-6
dc.identifier.fileWOS000409562000043.pdf
dc.identifier.issn2045-2322
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/57372
dc.identifier.wosWOS:000409562000043
dc.language.isoeng
dc.publisherNature Publishing Group
dc.relation.ispartofScientific Reports
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleFungicidal activity of peptides encoded by immunoglobulin genesen
dc.typeinfo:eu-repo/semantics/article
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