Exercise Training Reduces PGE(2) Levels and Induces Recovery from Steatosis in Tumor-bearing Rats

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dc.contributor.authorLira, Fabio dos Santos [UNIFESP]
dc.contributor.authorYamashita, Alex Shimura
dc.contributor.authorCarnevali, Luiz Carlos
dc.contributor.authorGonçalves, Daniela Caetano
dc.contributor.authorLima, Waldecir Paula
dc.contributor.authorRosa Neto, José Cesar [UNIFESP]
dc.contributor.authorCaperuto, Erico Chagas
dc.contributor.authorRosa, Luis Fernando Bicudo Pereira Costa
dc.contributor.authorSeelaender, Marilia Cerqueira Leite
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:05:46Z
dc.date.available2016-01-24T14:05:46Z
dc.date.issued2010-12-01
dc.description.abstractThe effects of endurance training on PGE(2) levels and upon the maximal activity of hepatic carnitine palmitoyltransferase (CPT) system were studied in rats bearing the Walker 256 carciosarcoma. Animals were randomly assigned to a sedentary control (SC), sedentary tumor-bearing (ST), exercised control (EC), and as an exercised tumor-bearing (ET) group. Trained rats ran on a treadmill (60% VO2 max) for 60 min/day, 5 days/week, for 8 weeks. We examined the mRNA expression (RT-PCR) and maximal activity (radio-assay) of the carnitine palmitoyltransferase system enzymes (CPT I and CPT II), as well as the gene expression of fatty-acid-binding protein (L-FABP) in the liver. PGE(2) content was measured in the serum, in tumor cells, and in the liver (ELISA). CPT I and CPT II maximal activity were decreased (p < 0.01) in ST when compared with SC. in contrast, serum PGE(2) was increased (p < 0.05) in cachectic animals as compared with SC. in the liver, PGE(2) content was also increased (p < 0.05) when compared with SC. Endurance training restored maximal CPT I and CPT II activity in the tumor-bearing animals (p < 0.0001). Exercise training induced PGE(2) levels to return to control values in the liver of tumor-bearing training rats (p < 0.05) and decreased the eicosanoid content in the tumor (p < 0.01). in conclusion, endurance training was capable of reestablishing liver carnitine palmitoyltransferase (CPT) system activity associated with decreased PGE(2) levels in cachectic tumor-bearing animals, preventing steatosis.en
dc.description.affiliationUniv São Paulo, Canc Metab Res Grp, Inst Biomed Sci, BR-05508900 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Physiol, Div Nutr Physiol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Physiol, Div Nutr Physiol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent944-U263
dc.identifierhttps://dx.doi.org/10.1055/s-0030-1267949
dc.identifier.citationJournal of Rare Earths. Amsterdam: Elsevier B.V., v. 28, n. 6, p. 944-U263, 2010.
dc.identifier.doi10.1055/s-0030-1267949
dc.identifier.issn1002-0721
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/33142
dc.identifier.wosWOS:000284944000025
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofJournal of Rare Earths
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectCachexiaen
dc.subjectExercise trainingen
dc.subjectCPT systemen
dc.subjectPGE(2) levelsen
dc.titleExercise Training Reduces PGE(2) Levels and Induces Recovery from Steatosis in Tumor-bearing Ratsen
dc.typeinfo:eu-repo/semantics/article
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