Influence of ACE I/D gene polymorphism in the progression of renal failure in autosomal dominant polycystic kidney disease: a meta-analysis

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dc.contributor.authorPereira, Tiago da Veiga [UNIFESP]
dc.contributor.authorNunes, Ane Claudia Fernandes
dc.contributor.authorRudnicki, Martina
dc.contributor.authorMagistroni, Ricardo
dc.contributor.authorAlbertazzi, Alberto
dc.contributor.authorPereira, Alexandre Costa
dc.contributor.authorKrieger, Jose Eduardo [UNIFESP]
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Fed Rio Grande Sul
dc.contributor.institutionUniv Modena
dc.date.accessioned2016-01-24T12:41:32Z
dc.date.available2016-01-24T12:41:32Z
dc.date.issued2006-11-01
dc.description.abstractBackground. Autosomal dominant polycystic kidney disease (ADPKD) is a renal disease characterized by an important variability in clinical course, which cannot be fully explained by the genetic heterogeneity of the disease. Although the role for the angiotensin I-converting enzyme (ACE) insertion/deletion (I/D) polymorphism as a modifier factor in ADPKD renal deterioration has been suggested, direct evidence from genetic association studies remain inconclusive. To provide a more robust estimate of the putative effect of the ACE I/D polymorphism on the renal progression in ADPKD, we performed a meta-analysis pooling data from all relevant studies in which the role of the ACE I/D variant in ADPKD clinical features was evaluated.Methods. We applied a random-effects model to combine odds ratio and 95% confidence intervals. Q-statistic was used to evaluate the homogeneity, and both Egger's and Begg-Mazumdar tests were used to assess publication bias.Results. Altogether, three distinct meta-analyses were generated using data from 13 studies. Despite the absence of publication bias and the presence of homogeneity among study results, the DD genotype failed to show an influence on risk of end-stage renal disease (ESRD), mean age at ESRD or risk of hypertension in ADPKD patients when compared with I-allele carriers (DD vs ID + II). Likewise, meta-analyses carried out separately for Caucasian and Asian studies showed no indication of an association between the DD genotype and a faster renal deterioration in ADPKD.Conclusion. These findings do not support the hypothesis that the enhanced ACE activity associated with the D allele might promote a significantly worse prognosis in patients with ADPKD.en
dc.description.affiliationUniv São Paulo, Sch Med, InCor Heart Inst, Lab Genet & Mol Cardiol, BR-05403000 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Biochem & Mol Biol, São Paulo, Brazil
dc.description.affiliationUniv Fed Rio Grande Sul, Med Sci & Nephrol Postgrad Program, Porto Alegre, RS, Brazil
dc.description.affiliationUniv São Paulo, Fac Pharmaceut Sci, Clin & Toxicol Anal Dept, São Paulo, Brazil
dc.description.affiliationUniv Modena, Div Nephrol Dialysis & Transplantat, I-41100 Modena, Italy
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Biochem & Mol Biol, São Paulo, Brazil
dc.description.provenanceMade available in DSpace on 2016-01-24T12:41:32Z (GMT). No. of bitstreams: 0 Previous issue date: 2006-11-01en
dc.description.sourceWeb of Science
dc.format.extent3155-3163
dc.identifierhttps://dx.doi.org/10.1093/ndt/gfl412
dc.identifier.citationNephrology Dialysis Transplantation. Oxford: Oxford Univ Press, v. 21, n. 11, p. 3155-3163, 2006.
dc.identifier.doi10.1093/ndt/gfl412
dc.identifier.issn0931-0509
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/29215
dc.identifier.wosWOS:000241277100024
dc.language.isoeng
dc.publisherOxford Univ Press
dc.relation.ispartofNephrology Dialysis Transplantation
dc.rightsAcesso aberto
dc.rights.licensehttp://www.oxfordjournals.org/access_purchase/self-archiving_policyb.html
dc.subjectACE gene polymorphismen
dc.subjectADPKDen
dc.subjectProgression of renal failureen
dc.subjectMeta-analysisen
dc.subjectAutosomal dominant polycystic kidney diseaseen
dc.titleInfluence of ACE I/D gene polymorphism in the progression of renal failure in autosomal dominant polycystic kidney disease: a meta-analysisen
dc.typeArtigo
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