Malnutrition as a prognostic factor in lymphoblastic-leukemia - a multivariate-analysis

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dc.contributor.authorViana, Marcos Borato
dc.contributor.authorMurao, Mitiko
dc.contributor.authorRamos, Gilberto
dc.contributor.authorOliveira, Hilda Maria
dc.contributor.authorCarvalho, Romeu Ibrahim de
dc.contributor.authorBastos, Marcos de
dc.contributor.authorColosimo, Enrico Antonio
dc.contributor.authorSilvestrini, Wagner Sérgio [UNIFESP]
dc.contributor.institutionUniversidade Federal de Minas Gerais (UFMG)
dc.contributor.institutionFELICIO ROCHO HOSP
dc.contributor.institutionIPSEMG BASE HOSP
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2018-06-15T13:56:00Z
dc.date.available2018-06-15T13:56:00Z
dc.date.issued1994-10-01
dc.description.abstractOne hundred and twenty eight Brazilian children with lymphoblastic leukaemia were intensively treated with a Berlin-Frankfurt-Munich based protocol. More children had a white cell count above 50 x 10(9)/1 (31%) then observed in developed countries. After a median follow up of 31 months (11-58 months), the estimated probability of relapse free survival was 41% (7%) for the whole group. After adjustment in the Cox's multivariate model, malnutrition was the most significant adverse factor affecting duration of complete remission. Age above 8 years and high peripheral white cell count were also significant adverse factors. Among the nutritional indices, the height for age and weight for age z scores were both significant, whether the cut off points of z-2 or z = -1.28 were chosen to define malnutrition. A strong statistical association between the two indices was found; the contribution of height for age z score to the prediction of relapse free survival was more significant. Children with height for age z score < -2 had a relapse risk of 8.2 (95% confidence interval 3.1 to 21.9) relative to children with z score > -2. The results of this study suggest that socioeconomic and nutritional factors should be considered in the prognostic evaluation of children with leukaemia in developing countries.en
dc.description.affiliationUNIV FED MINAS GERAIS,DIV HAEMATOL,BELO HORIZONT,MG,BRAZIL
dc.description.affiliationUNIV FED MINAS GERAIS,HOSP CLIN,DIV HAEMATOL,BELO HORIZONT,MG,BRAZIL
dc.description.affiliationFELICIO ROCHO HOSP,BELO HORIZONT,MG,BRAZIL
dc.description.affiliationIPSEMG BASE HOSP,BELO HORIZONT,MG,BRAZIL
dc.description.affiliationUNIV FED MINAS GERAIS,DEPT STAT,BELO HORIZONT,MG,BRAZIL
dc.description.affiliationESCOLA PAULISTA MED,DEPT PAEDIAT,SAO PAULO,BRAZIL
dc.description.affiliationUnifespESCOLA PAULISTA MED,DEPT PAEDIAT,SAO PAULO,BRAZIL
dc.description.sourceWeb of Science
dc.format.extent304-310
dc.identifierhttps://dx.doi.org/10.1136/adc.71.4.304
dc.identifier.citationArchives Of Disease In Childhood. London: British Med Journal Publ Group, v. 71, n. 4, p. 304-310, 1994.
dc.identifier.doi10.1136/adc.71.4.304
dc.identifier.issn0003-9888
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/42643
dc.identifier.wosWOS:A1994PK93900005
dc.language.isoeng
dc.publisherBritish Med Journal Publ Group
dc.relation.ispartofArchives Of Disease In Childhood
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleMalnutrition as a prognostic factor in lymphoblastic-leukemia - a multivariate-analysisen
dc.typeinfo:eu-repo/semantics/article
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