Morphological and functional response to injury to the external urethral sphincter - similarities and differences between male and female rats

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dc.citation.issue3
dc.citation.volume35
dc.contributor.authorNascimento, Scheila F. C. [UNIFESP]
dc.contributor.authorBispo, Ana Paula S. [UNIFESP]
dc.contributor.authorLeite, Katia Ramos
dc.contributor.authorPlapler, Helio
dc.contributor.authorFuellhase, Claudius
dc.contributor.authorSimonetti, Rogerio [UNIFESP]
dc.contributor.authorSoler, Roberto [UNIFESP]
dc.coverageHoboken
dc.date.accessioned2020-08-21T17:00:07Z
dc.date.available2020-08-21T17:00:07Z
dc.date.issued2016
dc.description.abstractAimsThe objective of this study was to evaluate the similarities and differences of the urethral morphological and functional changes following external urethral sphincter EUS injury in male and female rats. Methods30 female and 30 male age-matched Wistar rats were used in the experiments. Half of them underwent electrocauterization of the surrounding tissues lateral to the urethra at the level of the (EUS) and the others, a sham operation. At 2, 6, and 16 weeks after surgeries they underwent anesthetized cystometry, measurement of leak point pressure (LPP) and their urethras were harvested for morphological analyses. ResultsThere were no differences in cystometric parameters between sex-time-matched animals, ensuring normal bladder function in the manipulated animals. The mean LPP in male and female rats was lower compared with sham animals. Age-time-matched sham operated male rats exhibited a higher LPP compared with female rats. The reduction in LPP comparing electrocauterized and sham time-matched animals was more pronounced in male rats than in female rats. Electrocauterization produced urethral collagen deposition and nerve damage in both male and female animals. Muscle atrophy and disruption also occurred, being more evident in female rats. ConclusionsThe urethras of male and female rats exhibited a similar morphological and functional response to electrocauterization. The time-course evaluation revealed that the male animal model is as reliable, reproducible and long-lasting as the female model. Intact males had a higher LPP than female rats and the nerve injury led to a more drastic impairment of this mechanism. Neurourol. Urodynam. 35:371-376, 2016. (c) 2014 Wiley Periodicals, Inc.en
dc.description.affiliationUniv Fed Sao Paulo, Div Urol, Rua Napoleao de Barros 715,2 Andar, BR-04024900 Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, Sch Med, Dept Urol, Lab Med Invest LIM55, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Div Operat Tech & Expt Surg, Dept Surg, BR-04024900 Sao Paulo, Brazil
dc.description.affiliationUniv Rostock, Dept Urol, D-18055 Rostock, Germany
dc.description.affiliationUnifespUniv Fed Sao Paulo, Div Urol, Rua Napoleao de Barros 715,2 Andar, BR-04024900 Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Div Operat Tech & Expt Surg, Dept Surg, BR-04024900 Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent371-376
dc.identifierhttp://dx.doi.org/10.1002/nau.22718
dc.identifier.citationNeurourology And Urodynamics. Hoboken, v. 35, n. 3, p. 371-376, 2016.
dc.identifier.doi10.1002/nau.22718
dc.identifier.issn0733-2467
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/57876
dc.identifier.wosWOS:000372355700006
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofNeurourology And Urodynamics
dc.rightsAcesso restrito
dc.subjectexternal urethral sphincteren
dc.subjectleak point pressureen
dc.subjectstress urinary incontinenceen
dc.subjecturodynamicsen
dc.titleMorphological and functional response to injury to the external urethral sphincter - similarities and differences between male and female ratsen
dc.typeArtigo
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