Riboflavin and photoproducts in MC3T3-E1 differentiation

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dc.contributor.authorChaves Neto, Antonio Hernandes
dc.contributor.authorYano, Claudia Lumy
dc.contributor.authorParedes-Gamero, Edgar Julian [UNIFESP]
dc.contributor.authorMachado, Daisy
dc.contributor.authorJusto, Giselle Zenker [UNIFESP]
dc.contributor.authorPeppelenbosch, Maikel P.
dc.contributor.authorFerreira, Carmen Verissima
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Groningen
dc.date.accessioned2016-01-24T14:05:32Z
dc.date.available2016-01-24T14:05:32Z
dc.date.issued2010-10-01
dc.description.abstractPhotoderivatives of riboflavin can modulate the proliferation and survival of cancer cells. in this work, we examined the influence of riboflavin and photoderivatives on osteoblast differentiation induced by ascorbic acid and beta-glycerophosphate. These compounds decreased the osteoblast proliferation, increased the alkaline phosphatase activity, promoted a reduction in matrix metalloproteinase-2 activity and the decreased in the OPG/RANKL ratio. the effects of flavins on osteoblasts were unrelated to the antioxidant activity of these compounds. the biological activity of osteogenic medium containing riboflavin and its photoderivatives involved the activation of different signaling pathways (AKT, FAK, CaMKII), caspases-3, -8 and -9, and up-regulation of the expression and/or stabilization of osteoblastic transcription factors (Runx2 and beta-catenin). These findings suggest a potential use of flavins as adjuvants to improve bone metabolism. (C) 2010 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv Estadual Campinas, UNICAMP, Dept Bioquim, Inst Biol, BR-13083970 Campinas, SP, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Bioquim, São Paulo, Brazil
dc.description.affiliationUniv Groningen, Univ Med Ctr Groningen, Dept Cell Biol, NL-9713 AV Groningen, Netherlands
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Bioquim, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIDFAPESP: 06/00430-1
dc.format.extent1911-1919
dc.identifierhttp://dx.doi.org/10.1016/j.tiv.2010.07.026
dc.identifier.citationToxicology in Vitro. Oxford: Pergamon-Elsevier B.V., v. 24, n. 7, p. 1911-1919, 2010.
dc.identifier.doi10.1016/j.tiv.2010.07.026
dc.identifier.issn0887-2333
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/32961
dc.identifier.wosWOS:000283567500005
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofToxicology in Vitro
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectAscorbic aciden
dc.subjectDifferentiationen
dc.subjectbeta-Glycerophosphateen
dc.subjectOsteoblasten
dc.subjectRiboflavinen
dc.subjectSignalingen
dc.titleRiboflavin and photoproducts in MC3T3-E1 differentiationen
dc.typeinfo:eu-repo/semantics/article
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