Gastroesophageal Reflux Affects Sleep Quality in Snoring Obese Children

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dc.citation.issue1
dc.citation.volume19
dc.contributor.authorMachado, Rodrigo Strehl [UNIFESP]
dc.contributor.authorWoodley, Frederick W.
dc.contributor.authorSkaggs, Beth
dc.contributor.authorDi Lorenzo, Carlo
dc.contributor.authorEneli, Ihuoma
dc.contributor.authorSplaingard, Mark
dc.contributor.authorMousa, Hayat
dc.coverageSeoul
dc.date.accessioned2020-08-21T17:00:19Z
dc.date.available2020-08-21T17:00:19Z
dc.date.issued2016
dc.description.abstractPurpose: This study was performed to evaluate the quality of sleep in snoring obese children without obstructive sleep apnea (OSA); and to study the possible relationship between sleep interruption and gastroesophageal reflux (GER) in snoring obese children. Methods: Study subjects included 13 snoring obese children who were referred to our sleep lab for possible sleep-disordered breathing. Patients underwent multichannel intraluminal impedance and esophageal pH monitoring with simultaneous polysomnography. Exclusion criteria included history of fundoplication, cystic fibrosis, and infants under the age of 2 years. Significant association between arousals and awakenings with previous reflux were defined by symptom-association probability using 2-minute intervals. Results: Sleep efficiency ranged from 67-97% (median 81%). A total of 111 reflux episodes (90% acidic) were detected during sleep, but there were more episodes per hour during awake periods after sleep onset than during sleep (median 2.3 vs. 0.6, p=0.04). There were 279 total awakenings during the sleep study; 56 (20.1%) of them in 9 patients (69.2%) were preceded by reflux episodes (55 acid, 1 non-acid). In 5 patients (38.5%), awakenings were significantly associated with reflux. Conclusion: The data suggest that acid GER causes sleep interruptions in obese children who have symptoms of snoring or restless sleep and without evidence of OSA.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Pediat, Escola Paulista Med, Rua Cel Lisboa 826, BR-04023062 Sao Paulo, Brazil
dc.description.affiliationOhio State Univ, Div Pediat Gastroenterol, Columbus, OH 43210 USA
dc.description.affiliationOhio State Univ, Dept Pediat, Columbus, OH 43210 USA
dc.description.affiliationNationwide Childrens Hosp, Dept Pediat, Columbus, OH USA
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Pediat, Escola Paulista Med, Rua Cel Lisboa 826, BR-04023062 Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent12-19
dc.identifierhttp://dx.doi.org/10.5223/pghn.2016.19.1.12
dc.identifier.citationPediatric Gastroenterology Hepatology & Nutrition. Seoul, v. 19, n. 1, p. 12-19, 2016.
dc.identifier.doi10.5223/pghn.2016.19.1.12
dc.identifier.fileWOS000407721000002.pdf
dc.identifier.issn2234-8646
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/57940
dc.identifier.wosWOS:000407721000002
dc.language.isoeng
dc.publisherKorean Soc Pediatric Gastroenterology & Nutrition
dc.relation.ispartofPediatric Gastroenterology Hepatology & Nutrition
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectGastroesophageal refluxen
dc.subjectBesityen
dc.subjectSleep wake disordersen
dc.subjectChilden
dc.subjectElectric impedanceen
dc.subjectObstructive sleep apneaen
dc.titleGastroesophageal Reflux Affects Sleep Quality in Snoring Obese Childrenen
dc.typeinfo:eu-repo/semantics/article
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