Melanomacrophage functions in the liver of the caecilian Siphonops annulatus

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dc.citation.issue3
dc.citation.volume232
dc.contributor.authorGutierre, Robson Campos [UNIFESP]
dc.contributor.authorJared, Carlos
dc.contributor.authorAntoniazzi, Marta Maria
dc.contributor.authorCoppi, Antonio Augusto
dc.contributor.authorEgami, Mizue Imoto [UNIFESP]
dc.coverageHoboken
dc.date.accessioned2020-07-08T13:09:36Z
dc.date.available2020-07-08T13:09:36Z
dc.date.issued2018
dc.description.abstractMelanomacrophages are phagocytes that synthesize melanin. They are found in the liver and spleen of ectothermic vertebrates, and in the kidney of fish. In agnathan and elasmobranch fish, melanomacrophages are seen as isolated cells, and forming clusters in all the other vertebrates. The natural phagocytic activity of melanomacrophages is poorly characterized, as most of the research works have focused on induced phagocytic activity only. Furthermore, little is known about amphibian melanomacrophages, mainly about those in caecilians - wormlike amphibians in the order of Gymnophiona, which is the least known group of terrestrial vertebrates. The present research work aimed at the structure and function of hepatic melanomacrophages of Siphonops annulatus, a species largely found in South America. We identified the role of these cells in the control of circulating basophils (pro-melanogenic cells), in the turnover of liver collagen stroma and in the hemocatheresis, interrelated physiological mechanisms.en
dc.description.affiliationUniv Fed Sao Paulo, Escola Paulista Med, Dept Morphol & Genet, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Escola Paulista Med, Dept Neurol & Neurosurg, Sao Paulo, Brazil
dc.description.affiliationInst Butantan, Cell Biol Lab, Sao Paulo, Brazil
dc.description.affiliationUniv Surrey, Sch Vet Med, Fac Hlth & Med Sci, Guildford, Surrey, England
dc.description.affiliationUnifespUniv Fed Sao Paulo, Escola Paulista Med, Dept Morphol & Genet, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Escola Paulista Med, Dept Neurol & Neurosurg, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipCoordenacao de Aperfeicoamento de Pessoal de Nivel Superior - CAPES
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico - CNPq
dc.format.extent497-508
dc.identifierhttp://dx.doi.org/10.1111/joa.12757
dc.identifier.citationJournal Of Anatomy. Hoboken, v. 232, n. 3, p. 497-508, 2018.
dc.identifier.doi10.1111/joa.12757
dc.identifier.issn0021-8782
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/54090
dc.identifier.wosWOS:000424878800012
dc.language.isoeng
dc.publisherWiley
dc.relation.ispartofJournal Of Anatomy
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectamphibiaen
dc.subjectbasophilen
dc.subjectcaecilianen
dc.subjectKupffer cellen
dc.subjectliveren
dc.subjectmelaninen
dc.subjectmelanomacrophagesen
dc.titleMelanomacrophage functions in the liver of the caecilian Siphonops annulatusen
dc.typeinfo:eu-repo/semantics/article
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