Brain-Penetrating Angiotensin-Converting Enzyme Inhibitors and Cognitive Change in Patients with Dementia due to Alzheimer's Disease

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dc.contributor.authorOliveira, Fabricio Ferreira de [UNIFESP]
dc.contributor.authorBertolucci, Paulo Henrique Ferreira [UNIFESP]
dc.contributor.authorChen, Elizabeth Suchi [UNIFESP]
dc.contributor.authorSmith, Marilia de Arruda Cardoso [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:35:07Z
dc.date.available2016-01-24T14:35:07Z
dc.date.issued2014-01-01
dc.description.abstractControversy over benefits of angiotensin-converting enzyme inhibitors (ACEIs) for treatment of dementia due to Alzheimer's disease (AD) led to this alternative investigational approach by the employment of pharmacogenetic methods, correlating the cognitive change of patients with late-onset AD with the presence of common ACE gene promoter polymorphisms, and stratifying the sample in groups of patients who responded or not to the brain-penetrating ACEIs Captopril or Perindopril. A trend was found for treatment with brain-penetrating ACEIs to slow cognitive decline in AD patients with the haplotype rs1800764 (CC): rs4291 (TT) (p = 0.024), and also non-significantly for independent carriers of rs1800764 or rs4291.en
dc.description.affiliationFed Univ São Paulo UNIFESP, Escola Paulista Med, Dept Neurol & Neurosurg, São Paulo, Brazil
dc.description.affiliationFed Univ São Paulo UNIFESP, Escola Paulista Med, Dept Morphol & Genet, São Paulo, Brazil
dc.description.affiliationUnifespFed Univ São Paulo UNIFESP, Escola Paulista Med, Dept Neurol & Neurosurg, São Paulo, Brazil
dc.description.affiliationUnifespFed Univ São Paulo UNIFESP, Escola Paulista Med, Dept Morphol & Genet, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipBehavioral Neurology Section of Hospital São Paulo
dc.description.sponsorshipLaboratory of Genetics of the Federal University of São Paulo (UNIFESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extentS321-S324
dc.identifierhttp://dx.doi.org/10.3233/JAD-132189
dc.identifier.citationJournal of Alzheimers Disease. Amsterdam: Ios Press, v. 42, p. S321-S324, 2014.
dc.identifier.doi10.3233/JAD-132189
dc.identifier.issn1387-2877
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/37300
dc.identifier.wosWOS:000341595800034
dc.language.isoeng
dc.publisherIos Press
dc.relation.ispartofJournal of Alzheimers Disease
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.iospress.nl/service/authors/author-copyright-agreement/
dc.subjectAlzheimer's diseaseen
dc.subjectdementiaen
dc.subjectdrug therapyen
dc.subjectneurodegenerative diseasesen
dc.subjectneuropsychiatryen
dc.subjectpharmacogeneticsen
dc.titleBrain-Penetrating Angiotensin-Converting Enzyme Inhibitors and Cognitive Change in Patients with Dementia due to Alzheimer's Diseaseen
dc.typeinfo:eu-repo/semantics/article
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