Swimming against the current: genetic vaccination against Trypanosoma cruzi infection in mice

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dc.contributor.authorRodrigues, Mauricio Martins [UNIFESP]
dc.contributor.authorAlencar, Bruna Cunha Gondim de [UNIFESP]
dc.contributor.authorClaser, Carla [UNIFESP]
dc.contributor.authorTzelepis, Fanny [UNIFESP]
dc.contributor.authorSilveira, Eduardo Lani Volpe da [UNIFESP]
dc.contributor.authorHaolla, Filipe Augusto Bettencourt [UNIFESP]
dc.contributor.authorDominguez, Mariana Ribeiro [UNIFESP]
dc.contributor.authorVasconcelos, Jose Ronnie Carvalho de [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2018-06-18T11:04:01Z
dc.date.available2018-06-18T11:04:01Z
dc.date.issued2009-07-01
dc.description.abstractVaccines have had an unquestionable impact on public health during the last century. The most likely reason for the success of vaccines is the robust protective properties of specific antibodies. However, antibodies exert a strong selective pressure and many microorganisms, such as the obligatory intracellular parasite Trypanosoma cruzi, have been selected to survive in their presence. Although the host develops a strong immune response to T. cruzi, they do not clear the infection and instead progress to the chronic phase of the disease. Parasite persistence during the chronic phase of infection is now considered the main factor contributing to the chronic symptoms of the disease. Based on this finding, containment of parasite growth and survival may be one method to avoid the immunopathology of the chronic phase. In this context, vaccinologists have looked over the past 20 years for other immune effector mechanisms that could eliminate these antibody-resistant pathogens. We and others have tested the hypothesis that non-antibody-mediated cellular immune responses (CD4(+) Th1 and CD8(+) Tc1 cells) to specific parasite antigens/genes expressed by T. cruzi could indeed be used for the purpose of vaccination. This hypothesis was confirmed in different mouse models, indicating a possible path for vaccine development.en
dc.description.affiliationUniv Fed Sao Paulo, Escola Paulista Med, Ctr Interdisciplinar Terapia Gen CINTERGEN, BR-04044010 Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Escola Paulista Med, Dept Microbiol Imunol & Parasitol, BR-04044010 Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, Inst Ciencias Biomed, Dept Imunol, BR-05508 Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Escola Paulista Med, Ctr Interdisciplinar Terapia Gen CINTERGEN, BR-04044010 Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Escola Paulista Med, Dept Microbiol Imunol & Parasitol, BR-04044010 Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent281-287
dc.identifierhttps://dx.doi.org/10.1590/S0074-02762009000900037
dc.identifier.citationMemorias Do Instituto Oswaldo Cruz. Rio De Janeiro, Rj: Fundaco Oswaldo Cruz, v. 104, n. S1, p. 281-287, 2009.
dc.identifier.doi10.1590/S0074-02762009000900037
dc.identifier.fileS0074-02762009000900037.pdf
dc.identifier.issn0074-0276
dc.identifier.scieloS0074-02762009000900037
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/44890
dc.identifier.wosWOS:000269123500036
dc.language.isoeng
dc.publisherFundação Oswaldo Cruz
dc.relation.ispartofMemorias Do Instituto Oswaldo Cruz
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTrypanosoma cruzien
dc.subjectVaccineen
dc.subjectImmunityen
dc.titleSwimming against the current: genetic vaccination against Trypanosoma cruzi infection in miceen
dc.typeinfo:eu-repo/semantics/article
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