Biocompatibility of a porous alumina ceramic scaffold coated with hydroxyapatite and bioglass

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dc.contributor.authorKido, Hueliton Wilian
dc.contributor.authorRibeiro, Daniel Araki [UNIFESP]
dc.contributor.authorOliveira, Poliani de
dc.contributor.authorParizotto, Nivaldo Antonio
dc.contributor.authorCamilo, Claudia Cristiane
dc.contributor.authorFortulan, Carlos Alberto
dc.contributor.authorMarcantonio, Elcio
dc.contributor.authorSilva, Victor Hugo Pereira da [UNIFESP]
dc.contributor.authorRenno, Ana Claudia Muniz [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Carlos (UFSCar)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionSão Paulo State Univ UNESP
dc.date.accessioned2016-01-24T14:37:30Z
dc.date.available2016-01-24T14:37:30Z
dc.date.issued2014-07-01
dc.description.abstractThis study aimed to evaluate the osteointegration and genotoxic potential of a bioactive scaffold, composed of alumina and coated with hydroxyapatite and bioglass, after their implantation in tibias of rats. for this purpose, Wistar rats underwent surgery to induce a tibial bone defect, which was filled with the bioactive scaffolds. Histology analysis (descriptive and morphometry) of the bone tissue and the single-cell gel assay (comet) in multiple organs (blood, liver, and kidney) were used to reach this aim after a period of 30, 60, 90, and 180 days of material implantation. the main findings showed that the incorporation of hydroxyapatite and bioglass in the alumina scaffolds produced a suitable environment for bone ingrowth in the tibial defects and did not demonstrate any genotoxicity in the organs evaluated in all experimental periods. These results clearly indicate that the bioactive scaffolds used in this study present osteogenic potential and still exhibit local and systemic biocompatibility. These findings are promising once they convey important information about the behavior of this novel biomaterial in biological system and highlight its possible clinical application. (C) 2013 Wiley Periodicals, Inc.en
dc.description.affiliationFed Univ Sao Carlos UFSCar, Dept Physiotherapy, Postgrad Program Biotechnol, Sao Carlos, SP, Brazil
dc.description.affiliationFed Univ São Paulo UNIFESP, Dept Biosci, Santos, SP, Brazil
dc.description.affiliationUniv São Paulo, Dept Mech Engn, Sao Carlos, SP, Brazil
dc.description.affiliationSão Paulo State Univ UNESP, Dept Dept Periodontol, Araraquara, SP, Brazil
dc.description.affiliationUnifespFed Univ São Paulo UNIFESP, Dept Biosci, Santos, SP, Brazil
dc.description.sourceWeb of Science
dc.format.extent2072-2078
dc.identifierhttps://dx.doi.org/10.1002/jbm.a.34877
dc.identifier.citationJournal of Biomedical Materials Research Part A. Hoboken: Wiley-Blackwell, v. 102, n. 7, p. 2072-2078, 2014.
dc.identifier.doi10.1002/jbm.a.34877
dc.identifier.issn1549-3296
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/37918
dc.identifier.wosWOS:000337570400002
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofJournal of Biomedical Materials Research Part A
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.subjectAluminaen
dc.subjectBiocompatibilityen
dc.subjectDNA damageen
dc.subjectBone repairen
dc.titleBiocompatibility of a porous alumina ceramic scaffold coated with hydroxyapatite and bioglassen
dc.typeinfo:eu-repo/semantics/article
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