Impact of doxorubicin treatment on the physiological functions of white adipose tissue

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dc.citation.issue3
dc.citation.volume11
dc.contributor.authorBiondo, Luana Amorim
dc.contributor.authorLima Junior, Edson Alves
dc.contributor.authorSouza, Camila Oliveira
dc.contributor.authorCruz, Maysa Mariana [UNIFESP]
dc.contributor.authorCunha, Roberta Dourado Cavalcante da [UNIFESP]
dc.contributor.authorAlonso-Vale, Maria Isabel Cardoso [UNIFESP]
dc.contributor.authorOyama, Lila Missae [UNIFESP]
dc.contributor.authorNascimento, Claudia Maria da Penha Oller do [UNIFESP]
dc.contributor.authorPimentel, Gustavo Duarte
dc.contributor.authorSantos, Ronaldo Vagner Thomatieli dos [UNIFESP]
dc.contributor.authorLira, Fabio Santos de
dc.contributor.authorRosa Neto, José Cesar
dc.coverageSan Francisco
dc.date.accessioned2020-08-21T16:59:48Z
dc.date.available2020-08-21T16:59:48Z
dc.date.issued2016
dc.description.abstractWhite adipose tissue (WAT) plays a fundamental role in maintaining energy balance and important endocrine functions. The loss of WAT modifies adipokine secretion and disrupts homeostasis, potentially leading to severe metabolic effects and a reduced quality of life. Doxorubicin is a chemotherapeutic agent used clinically because of its good effectiveness against various types of cancer. However, doxorubicin has deleterious effects in many healthy tissues, including WAT, liver, and skeletal and cardiac muscles. Our objective was to investigate the effects of doxorubicin on white adipocytes through in vivo and in vitro experiments. Doxorubicin reduced the uptake of glucose by retroperitoneal adipocytes and 3T3-L1 cells via the inhibition of AMP-activated protein kinase Thr172 phosphorylation and glucose transporter 4 content. Doxorubicin also reduced the serum level of adiponectin and, to a greater extent, the expression of genes encoding lipogenic (Fas and Acc) and adipogenic factors (Pparg, C/ebpa, and Srebp1c) in retroperitoneal adipose tissue. In addition, doxorubicin inhibited both lipogenesis and lipolysis and reduced the hormone-sensitive lipase and adipose tissue triacylglycerol lipase protein levels. Therefore, our results demonstrate the impact of doxorubicin on WAT. These results are important to understand some side effects observed in patients receiving chemotherapy and should encourage new adjuvant treatments that aim to inhibit these side effects.en
dc.description.affiliationUniv Sao Paulo, Inst Biomed Sci, Dept Cellular Biol & Dev, Immunometab Res Grp, Sao Paulo, SP, Brazil
dc.description.affiliationFed Univ Sao Paulo UNIFESP, Inst Environm Sci Chem & Pharmaceut, Dept Biol Sci, Sao Paulo, SP, Brazil
dc.description.affiliationFed Univ Sao Paulo UNIFESP, Dept Physiol, Physiol Nutr Discipline, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Goias, Fac Nursing & Nutr, Goiania, Go, Brazil
dc.description.affiliationUniv Fed Sao Paulo UNIFESP, Dept Psychobiol, Sao Paulo, SP, Brazil
dc.description.affiliationState Univ Sao Paulo Julio de Mesquita Filho UNES, Dept Phys Educ, Presidente Prudente, SP, Brazil
dc.description.affiliationUnifespFed Univ Sao Paulo UNIFESP, Inst Environm Sci Chem & Pharmaceut, Dept Biol Sci, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespFed Univ Sao Paulo UNIFESP, Dept Physiol, Physiol Nutr Discipline, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo UNIFESP, Dept Psychobiol, Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt
dc.description.sponsorshipIDFAPESP: 2013/09367-4
dc.identifierhttps://dx.doi.org/10.1371/journal.pone.0151548
dc.identifier.citationPlos One. San Francisco, v. 11, n. 3, p. -, 2016.
dc.identifier.doi10.1371/journal.pone.0151548
dc.identifier.fileWOS000372708900026.pdf
dc.identifier.issn1932-6203
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/57771
dc.identifier.wosWOS:000372708900026
dc.language.isoeng
dc.publisherPublic Library Science
dc.relation.ispartofPlos One
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleImpact of doxorubicin treatment on the physiological functions of white adipose tissueen
dc.typeinfo:eu-repo/semantics/article
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