Evaluation of the anxiolytic-like effects of Cecropia glazioui Sneth in mice

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dc.contributor.authorRocha, F. F.
dc.contributor.authorLapa, A. J.
dc.contributor.authorDe Lima, TCM
dc.contributor.institutionUniversidade Federal de Santa Catarina (UFSC)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T12:33:11Z
dc.date.available2016-01-24T12:33:11Z
dc.date.issued2002-01-01
dc.description.abstractCecropia glazioui Sneth has been used in most Latin American countries as an antihypertensive, cardiotonic, and antiasthmatic folk medicine. in the cardiovascular studies to define its antihypertensive action it was noteworthy that animals treated with the aqueous extract (AE) of C. glazioui were much calmer than control animals. That observation prompted the present study, aimed at an investigation of the effects of AE and of two semipurified fractions on mouse behavior as evaluated in the elevated plus-maze test (EPM). Male adult Swiss mice were treated with AE (0.25-1 g/kg po) acutely (1 h) or repeatedly (24, 7, and 1.5 h before the test). After repeated administration of AE, the frequency of entries in the open arms of EPM was increased threefold. A similar profile of action was observed after treatment with the butanolic fraction (Fbut) but not with the aqueous fraction (Faq). These findings suggest that the AE of C. glazioui promotes an anxiolytic-like effect in mice. the active principles responsible for this action are present in the less polar fraction of the extract, the main constituents of which are flavonoids and terpenes, among other compounds. (C) 2002 Elsevier Science Inc. All rights reserved.en
dc.description.affiliationUniv Fed Santa Catarina, Ctr Biol Sci, Dept Pharmacol, Neuropharmacol Lab, BR-88039900 Florianopolis, SC, Brazil
dc.description.affiliationUNIFESP, Escola Paulista Med, Dept Pharmacol, Nat Prod Sect, BR-04044020 São Paulo, Brazil
dc.description.affiliationUnifespUNIFESP, Escola Paulista Med, Dept Pharmacol, Nat Prod Sect, BR-04044020 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent183-190
dc.identifierhttp://dx.doi.org/10.1016/S0091-3057(01)00695-5
dc.identifier.citationPharmacology Biochemistry and Behavior. Oxford: Pergamon-Elsevier B.V., v. 71, n. 1-2, p. 183-190, 2002.
dc.identifier.doi10.1016/S0091-3057(01)00695-5
dc.identifier.issn0091-3057
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/26697
dc.identifier.wosWOS:000173687300020
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofPharmacology Biochemistry and Behavior
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectanxietyen
dc.subjectmedicinal planten
dc.subjectvalidationen
dc.subjectphytomedicineen
dc.subjectplus-mazeen
dc.titleEvaluation of the anxiolytic-like effects of Cecropia glazioui Sneth in miceen
dc.typeinfo:eu-repo/semantics/article
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