Role of the medial septal area on pilocarpine-induced salivary secretion and water intake

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dc.contributor.authorPaulin, Renata Fabris
dc.contributor.authorMenani, Jose V.
dc.contributor.authorColombari, Eduardo [UNIFESP]
dc.contributor.authorDe Paula, Patricia Maria
dc.contributor.authorAlmeida Colombari, Debora Simoes
dc.contributor.institutionSão Paulo State Univ
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T13:58:50Z
dc.date.available2016-01-24T13:58:50Z
dc.date.issued2009-10-28
dc.description.abstractPeripheral injection of pilocarpine, a cholinergic muscarinic agonist, induces salivation, water intake and hypertension. the medial septal area (MSA) is involved in cardiovascular control and fluid-electrolyte balance. Therefore, the effects of lesions or muscarinic cholinergic blockade in the MSA on the salivation, water intake and pressor responses induced by peripheral pilocarpine (4 mu mol/kg of body weight) were investigated. Male Holtzman rats with stainless steel cannulas implanted in the MSA or submitted to electrolytic lesion of MSA were used. MSA lesion (I day) reduced the salivation (262 45 vs. sham: 501 +/- 30 mg/7 min) and water intake (2.6 +/- 0.4 vs. sham: 4 +/- 0.4 ml/1 h) induced by intraperitoneal pilocarpine, whereas 15-day MSA lesion reduced only the pilocarpine-induced water intake (2.3 +/- 0.5 ml/1 h). Pre-treatment with the muscarinic cholinergic antagonist atropine methyl bromide (4 nmol/0.5 mu l) into MSA also reduced the pilocarpine-induced salivation (420 +/- 33 mg/7 min) and water intake (1.4 +/- 0.4 ml/1 h). Conversely, MSA lesions or the blockade of muscarinic receptors in the MSA did not change the pressor response induced by intravenous pilocarpine. the results show that MSA and its muscarinic receptors are part of the forebrain circuitry activated by peripheral pilocarpine that induce salivary secretion and water intake. Moreover, they suggest that different central mechanisms are involved in the salivatory, dipsogenic and cardiovascular effects of peripheral pilocarpine in rats. (C) 2009 Elsevier B.V. All rights reserved.en
dc.description.affiliationSão Paulo State Univ, Fac Odontol, Dept Fisiol & Patol, UNESP,Sch Dent, BR-14801903 Araraquara, SP, Brazil
dc.description.affiliationUNIFESP EPM, Dept Physiol, São Paulo, Brazil
dc.description.affiliationUnifespUNIFESP EPM, Dept Physiol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIDFAPESP: 06/54716-3
dc.format.extent145-152
dc.identifierhttp://dx.doi.org/10.1016/j.brainres.2009.08.067
dc.identifier.citationBrain Research. Amsterdam: Elsevier B.V., v. 1298, p. 145-152, 2009.
dc.identifier.doi10.1016/j.brainres.2009.08.067
dc.identifier.issn0006-8993
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/31889
dc.identifier.wosWOS:000271557700014
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofBrain Research
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectSalivationen
dc.subjectThirsten
dc.subjectSalivary glanden
dc.subjectAtropineen
dc.subjectArterial pressureen
dc.subjectCholinergic receptoren
dc.titleRole of the medial septal area on pilocarpine-induced salivary secretion and water intakeen
dc.typeinfo:eu-repo/semantics/article
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